Revue médicale suisse
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Neuropathic pain is challenging to treat, partly because of the systemic side effects of the commonly used medications. Therefore topical analgesics are potentially very usefull. ⋯ However, this option should be evaluated on an individual basis. The efficacy of topical amitriptyline and ketamine is not demonstrated.
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We present the case of a end stage renal failure patient treated with haemodialysis who developed painful nodules of the subcutis which progressed to ulcerative and necrotic lesions, gradually spreading. The diagnosis of calcific uremic arteriolopathy was made, based on histologic findings showing adipose tissue with necrotic areas and calcifications of the arterioles's media. We describe the clinical presentation of this syndrome which is associated with a high mortality and resume the actual conceptions about the pathogenesis, the diagnosis, prevention and treatment.
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Revue médicale suisse · Apr 2008
Review[The biological treatments for moderate to severe plaque psoriasis].
Psoriasis is a chronic inflammatory skin disorder that can cause substantial disability. The recognition of psoriasis as an immunologically mediated disease led to the development of agents that specifically target key steps in the pathological process. In this review, we focus on the mechanism of action, the efficacy and the safety data of the new biological treatments: alefacept, efalizumab, etanercept, infliximab and adalimumab.