Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
A brain-machine interface for control of burst suppression in medical coma.
Burst suppression is an electroencephalogram (EEG) marker of profound brain inactivation and unconsciousness and consists of bursts of electrical activity alternating with periods of isoelectricity called suppression. Burst suppression is the EEG pattern targeted in medical coma, a drug-induced brain state used to help recovery after brain injuries and to treat epilepsy that is refractory to conventional drug therapies. The state of coma is maintained manually by administering an intravenous infusion of an anesthetic, such as propofol, to target a pattern of burst suppression on the EEG. ⋯ We compute the BSP in real time from the EEG segmented into a binary time-series by deriving a two-dimensional state-space algorithm. We then derive a stochastic controller using both a linear-quadratic-regulator strategy and a model predictive control strategy. The BMI can promptly change the level of burst suppression without overshoot or undershoot and maintains precise control of time-varying target levels of burst suppression in individual rodents in real time.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Analysis of fractal electrodes for efficient neural stimulation.
Planar electrodes are increasingly used in a variety of neural stimulation techniques such as epidural spinal cord stimulation, epidural cortical stimulation, transcranial direct current stimulation and functional electric stimulation. Recently, optimized electrode geometries have been shown to increase the efficiency of neural stimulation by maximizing the variation of current density on the electrode surface. In the present work, a new family of modified fractal electrode geometries is developed to increase the neural activation function and enhance the efficiency of neural stimulation. ⋯ Rigorous finite element simulations were performed to compute the distribution of electric potential produced by proposed geometries, demonstrating that the neural activation function was significantly enhanced in the tissue. The activation of 800 model axons positioned around the electrodes was also quantified, showing that modified fractal geometries yielded a 22% reduction in input power consumption while maintaining the same level of neural activation. The results demonstrate the feasibility of increasing stimulation efficiency using modified fractal geometries beyond the levels already reported in the literature.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Development of a diagnostic glove for unobtrusive measurement of chest compression force and depth during neonatal CPR.
Optimizing chest compression (CC) performance during neonatal cardiopulmonary resuscitation (CPR) is critical to improving survival outcomes since current clinical protocols often achieve only a fraction of the native cardiovascular perfusion. This study presents the development of a diagnostic tool to unobtrusively measure the CC depth and force during neonatal CPR using sensors mounted on a glove platform. ⋯ The TT method yielded maximum CC depths and forces of as much as 25.7 ± 3.2 mm and 35.9 ± 2.2 N while the TF method produced CC depths and forces of as much as 21.6 ± 2.2 mm and 23.7 ± 2.9 N. These results are consistent with clinical findings which suggest that TT compression is more effective than TF compression since it produces greater CC depths and forces.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Hemodynamics at the ostium of cerebral aneurysms with relation to post-treatment changes by a virtual flow diverter: a computational fluid dynamics study.
Computational fluid dynamics (CFD) techniques have been refined for modeling the hemodynamics in cerebral aneurysms. Recent interest has focused on understanding hemodynamic changes by treatment with a flow diverter (FD), i.e. a stent with a dense metal mesh which is placed across the ostium to divert the majority of flow away from the aneurysm. Potential complications include remnant inflow jets but, more seriously, aneurysm hemorrhage. ⋯ Velocities and WSS were reduced in all cases post FD treatment, pressure increased in one case. Heterogeneous distributions of the velocity magnitude were found at the ostium with focal maxima indicating potential risk zones for remnant inflow jets into the aneurysms. Pressures at the ostium correlated with pressure changes inside the aneurysm which could become a pre-treatment indicator for the evaluation of the suitability of a particular aneurysm for FD treatment.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
Electrical or repetitive transcranial magnetic stimulation of primary motor cortex for intractable neuropathic pain.
To assess the pain-relieving effects of motor cortex electrical stimulation (MCS) and the predictive factors retrospectively. ⋯ The test stimulation within the central sulcus was more effective than that of the precentral gyrus. In the selected patients, chronic stimulation within the central sulcus did not significantly improve long-term results. Repeated rTMS seems to be same effective as MCS.