Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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Electrical stimulation of the spinal cord is used for pain relief, and is in use for hundreds of thousands of cases of chronic neuropathic pain. In spinal cord stimulation (SCS), an array of electrodes is implanted in the epidural space of the cord, and electrical currents are used to stimulate nearby nerve fibers, believed to be in the dorsal columns of the cord. Despite the long history of SCS for pain, stretching over 30 years, its underlying mechanisms are poorly understood, and the therapy has evolved very little in this time. ⋯ The combination of these two models is used to predict which fibers may be recruited by a given stimulus, as well as to predict the ensuing recorded waveforms. The model is shown to reproduce major features of spinal compound action potentials, such as threshold and propagation behaviour, which have been observed in experiments. The model's coverage of processes from stimulation to recording allows it to be compared side-by-side with actual experimental data, and will permit its refinement to a substantial level of accuracy.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2013
A flexible algorithm framework for closed-loop neuromodulation research systems.
Modulation of neural activity through electrical stimulation of tissue is an effective therapy for neurological diseases such as Parkinson's disease and essential tremor. Researchers are exploring improving therapy through adjustment of stimulation parameters based upon sensed data. ⋯ The latter, known as the control policy algorithm, is the focus of this work. Because the optimal control policy algorithms for the nervous system are not fully characterized at this time, we have implemented a generic control policy framework to facilitate exploratory research and rapid prototyping of new neuromodulation strategies.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Validation of heart rate extraction using video imaging on a built-in camera system of a smartphone.
As a smartphone is becoming very popular and its performance is being improved fast, a smartphone shows its potential as a low-cost physiological measurement solution which is accurate and can be used beyond the clinical environment. Because cardiac pulse leads the subtle color change of a skin, a pulsatile signal which can be described as photoplethysmographic (PPG) signal can be measured through recording facial video using a digital camera. In this paper, we explore the potential that the reliable heart rate can be measured remotely by the facial video recorded using smartphone camera. ⋯ The heart rate was extracted using frequency analysis of the raw trace signal and the analyzed signal from ICA. The accuracy of the estimated heart rate was evaluated by comparing with the heart rate from reference electrocardiogram (ECG) signal. Finally, we developed FaceBEAT, an iPhone application for remote heart rate measurement, based on this study.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Controlled Clinical TrialPerformance of respiratory pattern parameters in classifiers for predict weaning process.
Weaning trials process of patients in intensive care units is a complex clinical procedure. 153 patients under extubation process (T-tube test) were studied: 94 patients with successful trials (group S), 38 patients who failed to maintain spontaneous breathing and were reconnected (group F), and 21 patients with successful test but that had to be reintubated before 48 hours (group R). The respiratory pattern of each patient was characterized through the following time series: inspiratory time (T(I)), expiratory time (T(E)), breathing cycle duration (T(Tot)), tidal volume (V(T)), inspiratory fraction (T(I)/T(Tot)), half inspired flow (V(T)/T(I)), and rapid shallow index (f/V(T)), where ƒ is respiratory rate. ⋯ We proposed the evaluation of these parameters using classifiers as logistic regression (LR), linear discriminant analysis (LDA), support vector machines (SVM) and classification and regression tree (CART) to discriminate between patients from groups S, F and R. An accuracy of 93% (98% sensitivity and 82% specificity) has been obtained using CART classification.
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Conf Proc IEEE Eng Med Biol Soc · Jan 2012
Stroke volume obtained from the brachial artery using transbrachial electrical bioimpedance velocimetry.
Stroke volume (SV) is the quantity of blood ejected by the cardiac ventricles per each contraction. When SV is multiplied by heart rate, cardiac output is the result. Cardiac output (CO), in conjunction with hemoglobin concentration and arterial oxygen saturation are the cornerstones of oxygen transport. ⋯ The technique involves passage of a constant magnitude, high frequency, and low amperage ac from the upper arm to the antecubital fossa. In all other respects, the operational aspects of TBEV are consistent with ICG. There is good evidence suggesting that the TBEV waveform and its derivatives are generated by blood resistivity changes only.