Revista médica de Chile
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Revista médica de Chile · May 2015
Review[Non-celiac gluten sensitivity: Another condition that responds to gluten].
Remission of gastrointestinal and general symptoms after gluten withdrawal has been described in some non-celiac individuals for nearly 30 years. Only recently, efforts have been made to define this entity, now referred to as "non-celiac gluten sensitivity". It includes patients that clinically respond to gluten free diet without exhibiting allergic or autoimmune features to explain such response. ⋯ Genetic and immune factors, changes in intestinal microbiota and non-gluten components present in wheat grains are main factors postulated in the pathogenesis of this condition. To date, there are no specific biomarkers for non-celiac gluten sensitivity and diagnosis is reached by excluding other causes of disease. A trial with gluten-free diet and subsequent gluten challenge is the methodology most frequently used to confirm diagnosis.
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Lack of adherence with medications is the main cause of antihypertensive treatment failure. ⋯ Only half of hypertensive patients comply with their antihypertensive therapy.