Antibiotiki i khimioterapii͡a = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR
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Antibiot. Khimioter. · Jun 1996
Clinical Trial[Use of pefloxacin in the treatment of infected burn wounds].
The efficacy of a home-made pefloxacin was estimated in clinico-laboratory trials including 25 patients with wound infection. The fluoroquinolone was used in a dose of 400 mg administered orally twice a day for 4-16 days. ⋯ The bacteriological efficacy amounted to 92 per cent. No side effects to the use of pefloxacin were observed.
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Antibiot. Khimioter. · Jun 1996
[Antibiotic sensitivity of Vibrio cholerae 01, isolated in the Ukraine in 1994].
One thousand and four hundred strains of V. cholerae 01 isolated in 1994 in the Ukraine were studied with respect to their antibiotic susceptibility and resistance. The study showed that it was possible not only to estimate the present tendencies in and the regularities of the change in their character but also to presuppose the probable circulation and incidence of the microbe based on the differences in the susceptibility, frequency and resistance pattern of the strains of V. cholerae 01 isolated from the environment and humans before and during the cholera outbreak. ⋯ The data are useful for cholera epidemic surveillance. However, the final conclusion is possible after investigation of the gene type pattern in the circulating V. cholerae strains.
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Antibiot. Khimioter. · Jan 1996
Clinical Trial[Ofloxacin in comprehensive treatment of infections in burn patients].
The experience with ofloxacin in the prophylaxis and treatment of infected burn wounds in 40 patients was investigated. High clinical and microbiological efficacy of the drug was stated (82.5 and 83 per cent respectively). The highest efficacy of ofloxacin was observed when the burned area did not exceed 25 per cent of the body surface. It was concluded that the prophylactic use of the drug during acute burn toxemia was not expedient.
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Antibiot. Khimioter. · Apr 1994
[Activity of ethics committees in clinical trials of antibacterial drugs].
Clinical trials are designed and conducted worldwide in accordance with International Rules of Good Clinical Practice (GCP). The guidelines are aimed at establishing a system ensuring personal integrity and welfare of trial subjects. ⋯ The experience of the local Ethics Committee of the Smolensk Medical Institute with protection of clinical trials of antibacterials is presented. The importance of setting up Ethics Committees for supervision of clinical trials in Russia is emphasized.