Mayo Clinic proceedings
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To evaluate the antidiabetic effects of the senolytic agent dasatinib in older patients with type 2 diabetes mellitus. ⋯ Dasatinib may have antidiabetic effects comparable to contemporary diabetic treatments and may be considered for use as a novel diabetic therapy. Future studies are needed to determine whether these results are translatable to patients with type 2 diabetes mellitus without underlying malignant diseases and to determine whether the antidiabetic effects of dasatinib are due to its senolytic properties.
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Mayo Clinic proceedings · Dec 2021
U-Shaped Association Between Duration of Sports Activities and Mortality: Copenhagen City Heart Study.
To investigate the association between the duration of weekly leisure-time sports activity and all-cause mortality. ⋯ We observed a U-shaped association between weekly duration of leisure sports activities and cardiovascular and all-cause mortality, with lowest risk for those participating in 2.6 to 4.5 weekly hours, being consistent across subgroups. Participation in sport activities should be promoted, but the potential risk of very high weekly hours of sport participation should be considered for inclusion in guidelines and recommendations.
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Mayo Clinic proceedings · Dec 2021
Observational StudyImplementation of a Comprehensive Patient Blood Management Program for Hospitalized Patients at a Large United States Medical Center.
To assess changes in inpatient transfusion utilization and patient outcomes with implementation of a comprehensive patient blood management (PBM) program at a large US medical center. ⋯ Patient blood management implementation for hospitalized patients in a large academic center was associated with substantial reductions in transfusion utilization and improved clinical outcomes. Broad-scale implementation of PBM in US hospitals is feasible without signal for patient harm.
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Mayo Clinic proceedings · Dec 2021
Development and Validation of a Multivariable Risk Prediction Model for COVID-19 Mortality in the Southern United States.
To evaluate clinical characteristics of patients admitted to the hospital with coronavirus disease 2019 (COVID-19) in Southern United States and development as well as validation of a mortality risk prediction model. ⋯ We have developed an easy-to-use, robust model for systematically evaluating patients presenting to acute care settings with COVID-19 infection.
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Mayo Clinic proceedings · Dec 2021
Electrocardiography-Based Artificial Intelligence Algorithm Aids in Prediction of Long-term Mortality After Cardiac Surgery.
To assess whether an electrocardiography-based artificial intelligence (AI) algorithm developed to detect severe ventricular dysfunction (left ventricular ejection fraction [LVEF] of 35% or below) independently predicts long-term mortality after cardiac surgery among patients without severe ventricular dysfunction (LVEF>35%). ⋯ A novel electrocardiography-based AI algorithm that predicts severe ventricular dysfunction can predict long-term mortality among patients with LVEF above 35% undergoing valve and/or coronary bypass surgery.