International journal of clinical and experimental medicine
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It is possible that brucellosis may be related to increase free radical production and antioxidant depletion. Thus, in the present study we aimed to evaluate the oxidative status in patient with brucellosis and healthy controls. ⋯ Brucellosis is an infection that is frequently seen in Mediterranean countries. This infection breaks the oxidant and antioxidant balance. In this disease, oxidant-antioxidant system indicators such as ceruloplasmin, total antioxidant capacity, total oxidant status and oxidative stress index can be used for showing the role of the brucella infection and for the monitoring of the treatment results.
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Sepsis-induced organ failure is the major cause of death, and is characterized by a massive dysregulated inflammatory response. The present study was to determine whether interleukin 6 (IL-6) expression was increased in sepsis rats and the roles of IL-6 in the damage of cardiac, liver and renal function in the sepsis rats. Sepsis rat models were elicited by intravenous injection of LPS. ⋯ IL-6 significantly reduced LVDP and average ±dP/dt, increased the activities of ALT and AST, and increased the concentration of creatinine in the sepsis rats. EX527, a sirtuin 1 (SIRT 1) inhibitor, blocked the effects of IL-6 in the sepsis rats. These results indicate that IL-6 plays important roles in the damage of cardiac, liver and renal function in the sepsis rats through SIRT 1.
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Transpulmonary thermodilution measurement is a convenient method for hemodynamic monitoring. However, the previously reported indicator temperature was not consistent. This study aimed to compare the accuracy of Pulse index Continuous Cardiac Output (PiCCO) monitoring using indicators of different temperatures. ⋯ PiCCO measurements with either indicator temperatures showed positive correlation with TEE results (P<0.05). The 0°C indicator had universally higher correlation coefficients than the 8°C indicator. So, PiCCO monitoring with the 0°C indicator might have better accuracy than the 8°C indicator.
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Endovascular aortic repair was first performed nearly two decades ago and has become a well-established alternative therapy for many thoracoabdominal aortic diseases. Early survival results with the endovascular aortic repair were impressive, but it also brought many complications. Aortoesophageal fistula is little-known and may be underestimated because it is an unusual complication of thoracic endovascular aortic repair. ⋯ Selecting flexibility and appropriate size stent graft, avoiding the thin aortic wall, and identifying the risk factors may reduce the morbidity of complications with aortoesophageal fistula after thoracic aortic aneurysm endovascular repair.
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Several studies have suggested that the menstrual cycle has the impact on sedation. No previous study has evaluated the effects of the menstrual cycle on sedation level and propofol requirement with preoperative intravenous dexmedetomidine. Sixty-four adult fertile women receiving general anesthesia for elective gynecologic surgery were included in the study. ⋯ From propofol administered to loss of eyelash reflex and BIS values reach to 50, propofol requirements were significantly least and duration were shortest in the LD group among the four groups. Menstrual cycle phases affect the sedation of propofol induction with preoperative intravenous dexmedetomidine, which is deeper in the luteal phase. We should cautious of excessive sedation by propofol anesthesia with preoperative dexmedetomidine in the luteal phase.