International journal of clinical and experimental medicine
-
To observe the change of PVI after thoracic epidural block on the basis of general anesthesia. ⋯ PVI can be used as a noninvasive indictor to monitor volume change after thoracic epidural block on the basis of general anesthesia.
-
An increasing number of studies have examined the ability of mesothelin to be a marker for the diagnosis of pancreatic cancer (PCa). The exact role of mesothelin needs to be elucidated. The aim of this study is to determine the overall accuracy of mesothelinin PCa through a meta-analysis of published studies. ⋯ Our findings suggest that mesothelin may be a useful diagnostic adjunctive tool for confirming PCa. However, further large scale studies are needed to confirm these findings.
-
The postoperative PCIA effects of dezocine in elderly patients were determined using a large multicenter randomized double-blind prospective study. ⋯ Dezocine combining with sufentanil is a complement drug for sufentanil in PCIA. Considering the side effects and overall satisfaction index, 0.1 mg/kg seems to be an ideal dosage for Dezocine using in the postoperative PCIA in elderly patients.
-
Levosimendan (LS) is a new inotropic drug which belongs to the group of drugs known as calcium sensitizers. It is different from other inotropic agents by its inotropic and vasodilatory actions without an increase in myocardial oxygen consumption and considered as a good choice in high-risk patients undergoing cardiac surgery. We aimed to investigate the proper time of the administration and the effect of prophylactic usage of LS in patients with low left ventricular ejection fraction (LVEF) undergoing coronary artery bypass grafting (CABG). ⋯ Our study shows that the elective preoperative initiation of LS especially 12 hours before the operation onset is associated with better improvement on cardiac functions as well as with lower mortality and complication rates, lower use of additional inotropic and vasopressor drugs, less need for intra-aortic balloon pump support and shorter length of stay in the ICU in patients with high perioperative risk or compromised left ventricular function. As a result, patients who received an infusion of LS 12 hours before surgery showed an evidence of less myocardial damage which suggested the preconditioning effect of the drug.
-
To investigate the therapeutic effects of a novel fluid resuscitation protocol (early fluid resuscitation plus 2% hydrogen inhalation) on acute kidney injury during septic shock induced by lipopolysaccharide in rats. ⋯ Early fluid resuscitation plus 2% hydrogen inhalation provided more protection against AKI during septic shock.