Dermatology online journal
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Melanoma of the oral cavity is a rare malignant disease that is often discovered in an advanced stage; survival time is an average of five years. Oral melanoma makes up from 0.2 to 8 percent of all melanomas. The presentation of this clinical case demonstrates the complexity of clinical and histopathological manifestations and poor prognosis of oral melanoma.
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Dermatol. Online J. · Jan 2008
Case ReportsFrostbite following use of a commercially available cryotherapy device for the removal of viral warts.
Warts are a common skin complaint in childhood. We describe 3 unusual cases in which inadvertent tissue injury was caused during the treatment of viral warts by a commercially available cryotherapy device. ⋯ If such devices are to remain available for public use we feel changes should be implemented to reduce the risk of such injuries occurring again in the future. Alternatively, cryotherapy as a treatment modality should remain in the realm of the trained health care professional.
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Dermatol. Online J. · Jul 2007
Randomized Controlled Trial Multicenter Study Comparative StudyTazarotene 0.1 percent cream plus clindamycin 1 percent gel versus tretinoin 0.025 percent gel plus clindamycin 1 percent gel in the treatment of facial acne vulgaris.
Topical retinoids are the cornerstone of therapy for acne vulgaris. Nevertheless, the adjunctive use of other anti-acne agents can help enhance the efficacy of topical retinoids still further. Given that tazarotene 0.1 percent gel has previously shown significantly greater efficacy than tretinoin 0.025 percent gel, it is likely that tazarotene plus clindamycin offers superior efficacy to tretinoin plus clindamycin, which has recently become available as a combination product. ⋯ Tazarotene/clindamycin also resulted in a significantly higher incidence of patients achieving > or = 50 percent global improvement (incidence of 88% vs. 75% at week 12; p< or =.05). Both regimens were similarly well tolerated. In the treatment of facial acne vulgaris, tazarotene plus clindamycin offers significantly greater efficacy than tretinoin plus clindamycin and has comparable tolerability.