Nan fang yi ke da xue xue bao = Journal of Southern Medical University
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Nan Fang Yi Ke Da Xue Xue Bao · Jun 2012
[Blocking p38 signal pathway lowers MMP-9 expression and reduces brain edema in rats with traumatic brain injury].
To explore the role of p38 signal pathway in regulating matrix metalloproteinase-9 (MMP-9) expression and brain edema formation in a rat model of traumatic brain injury (TBI). ⋯ Blocking p38 signal pathway can attenuate MMP-9 upregulation and brain edema after TBI, suggesting the important role of p38 in regulating MMP-9 expression to affect traumatic brain edema.
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Nan Fang Yi Ke Da Xue Xue Bao · Jun 2012
[Ulinastatin combined with thymosin α1 for treatment of severe sepsis: a histopathological observation in rats].
To evaluate the therapeutic effect of ulinastatin combined with thymosin α1 in the treatment of severe sepsis in rats. ⋯ Combined treatment with ulinastatin and thymosin α1 can significantly improve the prognosis and ameliorate organ damage and spleen cell apoptosis in rats with sever sepsis.
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Nan Fang Yi Ke Da Xue Xue Bao · May 2012
[Topical application of leptin promotes burn wound healing in rats].
To investigate the effect of topical application of leptin in promoting burn wound healing in rats. ⋯ Topical application of leptin can promote re-epithelization in burn wounds to shorten the wound healing time of burns.
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Nan Fang Yi Ke Da Xue Xue Bao · Apr 2012
Comparative Study[Effect of clopidogrel combined with calcium-channel blocker on coronary artery disease in elderly patients: a propensity score-based retrospective cohort study].
To compare the effects of clopidogrel combined with dihydropyridine calcium-channel blockers (CCBs) or non-dihydropyridine CCBs on coronary artery disease (CAD) in elderly patients. ⋯ Compared with clopidogrel without CCB, clopidogrel with CCB does not increase the mortality or composite thromboembolic events in elderly CAD patients, but clopidogrel combined with non-dihydropyridine CCB is associated with significantly increased composite thromboembolic events in comparison with dihydropyridine CCB.
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Nan Fang Yi Ke Da Xue Xue Bao · Mar 2012
[Effects of somatostatin in a rabbit model of abdominal compartment syndrome induced by prolonged intra-abdominal hypertension].
To establish a rabbit model of abdominal compartment syndrome (ACS) induced by prolonged intra-abdominal hypertension (IAH) and evaluate the therapeutic effect of somatostatin on ACS. ⋯ Prolonged IAH causes cardiovascular function damages in rabbits possibly related to acidosis, electrolyte disturbances, and oxidative damage due to tissue ischemia and hypoxia. Somatostatin produces no obvious protective effects against the occurrence and progression of ACS.