Vox sanguinis
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Comparative Study Clinical Trial Controlled Clinical Trial
Effects of solvent/detergent-treated plasma and fresh-frozen plasma on haemostasis and fibrinolysis in complex coagulopathy following open-heart surgery.
Solvent/detergent-treated plasma (SDP) contains markedly lower protein S (PS) and plasmin inhibitor (PI) activity than standard fresh-frozen plasma (FFP). It has also been reported that SDP contains no alpha(1)-antitrypsin. Despite the lack of clinical data, it is suspected that SDP may be less effective than FFP in the treatment of complex coagulopathies. We therefore conducted a prospective trial to study the impact of SDP and FFP on haemostasis and fibrinolysis in complex coagulopathy after open-heart surgery. ⋯ With the exception of PS and PI, SDP and FFP improved haemostasis and fibrinolysis to a similar degree. The clinical significance of these findings has to be determined in patients with severe acquired PS and PI deficiency requiring plasma transfusions.
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Randomized Controlled Trial Comparative Study Clinical Trial
Humoral immune response to autologous blood transfusion in hip surgery: whole blood versus packed red cells and plasma.
The immune response to the transfused autologous buffy coat content in whole blood has, to date, not been studied in detail. ⋯ In comparison to the impact of surgery on cytokine and complement levels, the transfusion of autologous buffy coat is not relevant.
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Multicenter Study Comparative Study
Evaluation of donor arm disinfection techniques.
To validate a standardized optimal national procedure for donor arm disinfection. ⋯ The Medi-Flex disinfection method offers the English National Blood Service a validated, optimal 'best practice' disinfection technique and should contribute significantly to the reduction in risk of transmission of bacteria by transfusion.
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High cell counts in granulocyte colony-stimulating factor (G-CSF)-mobilized granulocytes are detrimental to concentrate storage. An eightfold dilution with autologous plasma improves storage, but this method is impractical. The purpose of this study was to identify an infusible solution that could be used in place of autologous plasma to dilute and store granulocytes. ⋯ Culture media were best for granulocyte storage, but they are not approved for in vivo use. Infusible solutions are not buffered adequately and lack sufficient protein, but infusible solutions, such as lactated Ringer's solution or Plasma-Lyte A supplemented with buffers and albumin, hold promise as effective and licensable solutions for granulocyte storage.
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Multicenter Study Comparative Study
Validity of the haemoglobin colour scale in blood donor screening.
The haemoglobin colour scale (HCS) has been developed as a simple, reliable and inexpensive clinical device for diagnosing anaemia and estimating its severity when laboratory-based haemoglobinometry is not available. The purpose of this study was to assess its validity for screening blood donors for anaemia. ⋯ The operators were able to master the HCS technique after a few minutes of practice, and all found the test to be user friendly and easy to read. The HCS is proposed as a replacement for the copper sulphate method for blood transfusion donor selection.