Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
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Zh Vopr Neirokhir Im N N Burdenko · Jan 2012
[Analysis of radiological criteria correlation and clinical manifestation of central lumbosacral spinal stenosis].
to assess the correlation analysis of radiologic criteria referred to central degenerative spinal stenosis and intensity of clinical manifestation. ⋯ analysis of our patients group demonstrated absence of correlation between intensity level of degenerative central spinal stenosis based on neurovisualization methods and intensity of its clinical manifestation. Pearson's coefficient of correlation and Spearmen rank correlation for variable which evaluates clinical signs (DDIL in %) and neurovisualization data (antero-posterior diameter of the spinal canal (mm), interfacet interval (mm), and cross-section area of the spinal canal (mm2)) are not significant to zero (p > 0.2).
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Zh Vopr Neirokhir Im N N Burdenko · Jan 2012
[Simvastatin efficacy in vasospasm treatment in patients after aneurysm SAH].
Number of trials had previously demonstrated cerebroprotective effect of statin therapy in SAH patients. Aim of the current study was to assess effects of simvastatin on vasospasm in clinical practice. The study group comprised 35 patients admitted to Burdenko Neurosurgery Institute with aneurysmal SAH in 2007-2011. ⋯ Statin group showed significantly lower rates of vasospam progression--42.9% vs. 76.7% in control (chi2-test, p = 0.01). Our evidence corresponds with outcomes of international trials of statin application in SAH patients. As follows from our results and existing randomized and clinical trials data there is no strong evidence nowadays to recommend statin prescription in SAH patients.
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Zh Vopr Neirokhir Im N N Burdenko · Jan 2012
[Optimizing blood pressure in patients with sellar region tumors during complicated postoperative period].
Mechanism of arterial hypotension (AH) in patients with sellar region tumors (SRT) and complicated postoperative period consists in decrease of systemic vascular resistance and relative hypovolemia. Therapeutic directions for blood pressure (BP) stabilization are clear. However criteria of optimal BP in these patients are absent. ⋯ In patients with complicated postoperative period and normal BP SjvO2 remains decreased. In patients with complicated postoperative period and arterial hypotension normal level of SjvO2 can be achieved if mean BP is increased up to 100-110 mmHg. SjvO2 normalization can improve outcomes in patients with SRT and complicated postoperative period.
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Zh Vopr Neirokhir Im N N Burdenko · Jan 2011
Review[Proton "radiosurgery" of cerebral arteriovenous malformations].
Arteriovenous malformations (AVM) are vascular lesions arising from impaired angiogenesis at the stage of transformation of primary embryonic arteriovenous anastomoses into capillaries. Commonly AVMs manifest with spontaneous hemorrhage. ⋯ In addition, stereotactic radiosurgery is used either as a component of complex management of large AVMs or pre-planned procedure combined with endovascular intervention, or as a second line therapeutic option in residual AVM after subtotal surgical resection. Comparing with photons protons due to their unique physical properties have advantages in spatial spread of dose thus allowing to significantly decrease integral dose to the surrounding brain tissue when treating large AVMs with complex shape proximal to critical structures.