Prescrire international
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About 1 additional ovarian cancer per 1000 women exposed to post- menopausal hormone replacement therapy for 5 years.
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Prescrire international · Dec 2015
Comparative StudyComparative advantages of new drugs: French Pharmacoeconomic Committee is not sufficiently demanding.
In France, the Pharmacoeconomic Committee (Commission de la Transparence) is responsible for assessing the therapeutic value of new drugs and their therapeutic advantages over existing therapies. These assessments are used in particular by public authorities to guide reimbursement policy, to decide whether to approve the drug's use in hospitals and other healthcare institutions, and to negotiate its price. Prescrire evaluates the therapeutic advantages of new drugs marketed in France (including products not reimbursed by the national health insurance system) and new indications, to help prescribers and patients make informed treatment choices. ⋯ The Pharmacoeconomic Committee is less concerned with ease of use, and more often considers positively drugs approved for situations in which there is a pressing need for better treatments, even when their efficacy is slight and poorly established. Prescrire's assessments are based on explicit procedures: a literature search; analysis of the evidence for efficacy; analysis of adverse effects; systematic consideration of treatment convenience, including packaging quality; and a systematic rating system. In addition, our ratings are free of any influence from the pharmaceutical industry.
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Prescrire international · Nov 2015
Review Comparative StudyE-cigarettes and smoking cessation. Similar efficacy to other nicotine delivery devices, but many uncertainties.
E-cigarettes, marketed as an alternative to conventional cigarettes, are designed to transform a solution of variable composition, with or without nicotine, into an aerosol that the user inhales. How effective are e-cigarettes as an aid to smoking cessation, and what are their known adverse effects? To answer these questions, we conducted a review of the literature using the standard Prescrire methodology. A randomised trial involving 657 individuals who wanted to stop smoking compared e-cigarettes (with or without nicotine) with nicotine patches. ⋯ Apart from the effects of nicotine, there are few known adverse effects. However, there are many uncertainties as to the composition of the different e-liquids and the long-term effects of the substances when they are heated and inhaled. There is no reason to discourage smokers from substituting the proven, serious harms of tobacco smoke with the potential and poorly defined harms associated with e-cigarettes.
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Prescrire international · Nov 2015
Obstacles to transparency over pharmacovigilance data within the EMA.
In July and August 2014, the European Medicines Agency (EMA) organised two public consultations concerning European pharmacovigilance. These two consultations reveal a number of EMA proposals that are counterproductive to the objective of improving transparency over pharmacovigilance data. The EMA's proposals offer pharmaceutical companies an opportunity to participate in public hearings held by the European Pharmacovigilance Risk Assessment Committee (PRAC), in order to defend their drug. ⋯ The strings attached to the access that the EMA proposes to grant researchers to data contained in the centralised European pharmacovigilance database would allow the EMA to censor the publication of their findings. The EMA seems to regard pharmacovigilance data as commercially confidential information. Responding to these consultations provided an opportunity to remind the EMA that data about adverse effects are a public good, in the common interest, and that it is unacceptable to keep this information confidential.