Yonsei medical journal
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Yonsei medical journal · Nov 2014
ATP-based chemotherapy response assay in primary or recurrent ovarian and peritoneal cancer.
To investigate chemosensitivity with an adenosine triphosphate-based chemotherapy response assay in patients with epithelial ovarian or peritoneal cancer according to tumor histology, grade, and disease status. ⋯ Ifosfamide and paclitaxel were the most active drugs for primary and recurrent disease. Therefore, we recommend further clinical studies to confirm the efficacy of paclitaxel, ifosfamide, and cisplatin combination chemotherapy for recurrent and primary ovarian cancer.
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Yonsei medical journal · Nov 2014
Case ReportsUsefulness of permanent tracheostoma in chronic brain injured patients: a case series.
Patients with severe neurological deficit, such as hypoxic ischemic injury, cerebral infarction, and traumatic brain injury, often show comatose mental status and require maintenance of long-term tracheostomy for pulmonary toileting. However, several complications, which are mostly related to the cannula, invariably occur. ⋯ This case report illustrates 3 cases of vegetative patients in our rehabilitation clinic who underwent successful procedure of permanent tracheostoma. Permanent tracheostoma has some benefits associated with the free of tube-related complications, and can be considered as a useful alternative way for chronic brain injured patients with long-term tracheostomy.
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Yonsei medical journal · Nov 2014
Effects of hippotherapy on gross motor function and functional performance of children with cerebral palsy.
The purpose of our study was to investigate the effects of hippotherapy on gross motor function and functional performance in children with spastic cerebral palsy (CP). ⋯ The results of our study demonstrate the beneficial effects of hippotherapy on gross motor function and functional performance in children with CP compared to control group. The significant improvement in PEDI-FSS scores suggests that hippotherapy may be useful to maximize the functional performance of children with CP.
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Yonsei medical journal · Nov 2014
Erratum to "Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation" by Lim BJ, et al. (Yonsei Med J 2011;52:610-5.).
[This corrects the article on p. 610 in vol. 52, PMID: 21623603.].
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Yonsei medical journal · Nov 2014
DNA hypomethylation-mediated overexpression of carbonic anhydrase 9 induces an aggressive phenotype in ovarian cancer cells.
Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads to an aggressive cancer cell phenotype. We examined epigenetically regulated genes that are involved in ovarian cancer metastasis. ⋯ Alterations in the DNA methylation profile of the CA9 promoter were correlated with a more aggressive phenotype in ovarian cancer cells.