Yonsei medical journal
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Yonsei medical journal · Jan 2017
Erratum to "Clinical Experience with the Bentall Procedure: 28 Years" by Joo HC, et al. (Yonsei Med J 2012;53:915-23.).
This corrects the article on p. 915 in vol. 53, PMID: 22869473.
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Yonsei medical journal · Jan 2017
Dose-Response Relationship between Alanine Aminotransferase Levels within the Reference Interval and Metabolic Syndrome in Chinese Adults.
Elevation in serum alanine aminotransferase (ALT) levels is a biomarker for metabolic syndrome (MS); however, the relationship has not been fully investigated within the reference interval of ALT levels. Our objective was to explore the relationship between serum ALT levels within the reference interval and MS in Chinese adults. ⋯ Serum ALT levels within the reference interval are positively associated with MS in a dose-response manner. Elevated ALT levels, even within the reference interval, may reflect early dysmetabolic changes.
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Yonsei medical journal · Jan 2017
Impact of Diltiazem Alone versus Diltiazem with Nitrate on Five-Year Clinical Outcomes in Patients with Significant Coronary Artery Spasm.
Calcium channel blockers diltiazem and nitrate have been used as selective coronary vasodilators for patients with significant coronary artery spasm (CAS). However, no study has compared the efficacy of diltiazem alone versus diltiazem with nitrate for long-term clinical outcomes in patients with CAS. ⋯ Despite the expected improvement of endothelial function and the relief of CAS, the combination of diltiazem and nitrate treatment was not superior to diltiazem alone in reducing mortality and cardiovascular events up to 5 years in patients with significant CAS.
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Yonsei medical journal · Jan 2017
Costs Attributable to Overweight and Obesity in Working Asthma Patients in the United States.
To estimate annual health care and productivity loss costs attributable to overweight or obesity in working asthmatic patients. ⋯ Health care and productivity loss costs attributable to overweight and obesity in asthma patients are substantial. This study's results highlight the importance of effective public health and educational initiatives targeted at reducing overweight and obesity among patients with asthma, which may help lower the economic burden of asthma.
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Yonsei medical journal · Jan 2017
Aberrant Hypomethylation of Solute Carrier Family 6 Member 12 Promoter Induces Metastasis of Ovarian Cancer.
Ovarian cancer (OC) is the most fatal of gynecological malignancies with a high rate of recurrence. We aimed to evaluate the expression of solute carrier family 6, member 12 (SLC6A12) and methylation of its promoter CpG sites in a xenograft mouse model of metastatic OC, and to investigate the regulatory mechanisms that promote aggressive properties during OC progression. ⋯ Our findings provide novel evidence for the biological and clinical significance of SLC6A12 as a metastasis-promoting gene.