Yonsei medical journal
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Yonsei medical journal · Jan 2018
Variants of Lipolysis-Related Genes in Korean Patients with Very High Triglycerides.
We investigated the prevalence and characteristics of variants of five lipolysis-related genes in Korean patients with very high triglycerides (TGs). Twenty-six patients with TG levels >885 mg/dL were selected from 13545 Korean subjects. Five candidate genes, LPL, APOC2, GPIHBP1, APOA5, and LMF1, were sequenced by targeted next-generation sequencing. ⋯ G533T variant of APOA5 were most frequent and found in 15 (57.7%) and 14 (53.8%) patients, respectively. Rare homozygous variants of the genes were very uncommon, while diverse rare heterozygous variants were commonly identified. Taken together, most study subjects may be manifesting the combined effects of rare heterozygous variants and common variants.
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Yonsei medical journal · Jan 2018
Protective Effects of Female Reproductive Factors on Lauren Intestinal-Type Gastric Adenocarcinoma.
Gastric cancer shows a male predominance that might be explained by protective effects from estrogens in females. Two Lauren classification histological subtypes, intestinal and diffuse, have distinct carcinogeneses. The purpose of this study was to estimate the effects of sex hormone on female gastric cancer according to Lauren classification. ⋯ These findings support that female sex hormones might be protective against intestinal-type gastric cancer.