Multiple sclerosis and related disorders
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Mult Scler Relat Disord · May 2019
Increased cerebrospinal fluid neurofilament light chain in central nervous system inflammatory demyelinating disease.
Central nervous system (CNS) inflammatory demyelinating disease (IDD) is an immune-mediated disease that is pathologically characterized by demyelination and inflammatory infiltration in the CNS and includes clinically isolated syndrome (CIS), multiple sclerosis (MS), and neuromyelitis optica spectrum disorders (NMOSD). IDD is usually characterized by variable symptoms, multivariate imaging, uncertain reactions to treatment, and a variable prognosis, which makes it difficult to diagnose early. In recent years, the role of the neurofilament light chain (NFL), an axonal injury biomarker, in IDD has become increasingly important. We will detect and analyse cerebrospinal fluid (CSF) NFL levels in IDD and normal control patients to determine the significance of NFL in the diagnosis and prognostic prediction of IDD. ⋯ The NFL level of CSF is conducive to assessing the severity and probable progress of IDD but is not helpful in distinguishing IDD among Chinese.
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Mult Scler Relat Disord · Feb 2019
Meta AnalysisPilates for people with multiple sclerosis: A systematic review and meta-analysis.
Pilates can be an interesting rehabilitation strategy for people with multiple sclerosis (MS), since is a low-cost and attractive physical exercise modality that has shown to have beneficial effects in other neurological pathologies. For prescribing Pilates to this population, health professionals should be aware of its potential benefits, a goal that can be achieved by making available updated scientific evidence in this regard. Therefore, the purpose of this study was to conduct a systematic review and a meta-analysis aimed at identifying the characteristics and methodological quality of the investigations that have studied the effects of Pilates in people affected with MS. ⋯ Pilates is a feasible therapy for people with MS that can lead to improvements on their physical function, and it might be helpful for reducing self-perceived fatigue. The potential beneficial effects of Pilates are not significantly greater than those derived from the performance of other physical therapies. Further high-quality RCTs are needed to consolidate the existing scientific evidence regarding the impact of Pilates on this population.
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Mult Scler Relat Disord · Jan 2019
ReviewAutoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review.
Neuromyelitis Optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS) which predominantly involves optic nerves and spinal cord. Since the introduction of Neuromyelitis Optica Spectrum Disorders (NMOSD) as a separate entity, there have been many reports on its association with other disorders including systemic and organ-specific autoimmune diseases. Here, we reviewed other immune-mediated diseases associated with NMOSD and tried to categorize them. ⋯ NMOSD may be associated with a variety of different types of autoimmune diseases. Therefore, systemic or laboratory signs which are not typical for NMOSD should be properly investigated to exclude other associated comorbidities. These comorbidities may affect the treatment strategy and may improve the patients' care and management.
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Mult Scler Relat Disord · Jan 2019
Color Doppler imaging evaluation of blood flow parameters in ophthalmic and posterior ciliary arteries and optic nerve diameter in chronic optic neuritis in multiple sclerosis patients.
Optic neuritis (ON) is a common clinical manifestation of Multiple Sclerosis (MS), which is associated with reduced visual acuity, blurred vision, blindness and retro-bulbar pain. In several studies, specific relations between optic nerve diameter and hemodynamics of the eye bulb arteries with ON have been reported. However, no consensus has been reached in this regard. We aim at determining the alterations in optic nerve diameter and eye bulb arteries hemodynamics in ON in MS patients. ⋯ These results indicate that there is a significant relation between eye involvement and increased optic nerve diameter in MS patients with chronic ON. While, there were no significant relations in EDV, PSV, RI and PI in PCA and OA comparing two groups.