Restorative neurology and neuroscience
-
Restor. Neurol. Neurosci. · Jan 2011
Comparative StudyNeuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia.
To assess the longterm neuroprotective effects of progesterone (P₄) and allopregnanolone (ALLO) on functional and morphological parameters of the integrity of the hippocampus, after global cerebral ischemia. ⋯ Performance of P₄ or ALLO treated rats in learning and memory tests suggests that these steroids promoted neural conditions accounting for adequate functioning long after ischemia, in spite of the loss of hippocampal pyramidal neurons.
-
Restor. Neurol. Neurosci. · Jan 2011
Comparative StudyImproved behavioral outcomes after progesterone administration in aged male rats with traumatic brain injury.
Twenty-month-old male Fischer 344 rats with bilateral contusions of the frontal cortex (n=8/group) or sham operations received 16 mg/kg of progesterone or vehicle at 1 and 6 h post-injury, then once every 24 h for the next seven days, with tapering of the dose over the final two treatments. The rats' behavioral recovery was then evaluated on tests of locomotor activity and Morris water maze learning. ⋯ The progesterone-treated rats had better functional outcomes than vehicle-treated rats with similar cortical injuries. The neurosteroid treatment did not affect the size of the necrotic cavity.
-
Restor. Neurol. Neurosci. · Jan 2011
Treatment with nerve grafts and aFGF attenuates allodynia caused by cervical root transection injuries.
Nerve root traction injuries induce spinal cord inflammation and lead to neuronal death within days. In the present study, we examined the inflammatory response one week after multiple cervical root transections. ⋯ This study demonstrated a correlation between an increased number of IL-1β-positive astrocytes and the development of allodynia. Our treatment significantly decreased IL-1β-positive astrocytes, thus preventing the occurrence of neuropathic pain following multiple cervical root injuries.