Archives of general psychiatry
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Arch. Gen. Psychiatry
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Arch. Gen. Psychiatry · Feb 2008
Randomized Controlled TrialGlutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study.
Ketamine evokes psychosislike symptoms, and its primary action is to impair N-methyl-D-aspartate glutamate receptor neurotransmission, but it also induces secondary increases in glutamate release. ⋯ These 2 changes may underpin 2 fundamental processes of psychosis: abnormal perceptual experiences and impaired cognitive-emotional evaluation of their significance. The results are compatible with the theory that the neural and subjective effects of ketamine involve increased glutamate release.