Annals of palliative medicine
The most recent articles from:
Ann Palliat Med
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Randomized Controlled Trial Multicenter Study
Genetic biomarkers associated with response to palliative radiotherapy in patients with painful bone metastases.
Palliative radiotherapy (RT) is effective in patients with painful bone metastases. Genetic factors may identify subgroup of patients who responded to RT. To identify DNA biomarkers associated with response to palliative RT. ⋯ SNVs involved in mechanisms including DNA repair, inflammation, cellular adhesion, and cell signalling have significant associations with radiation response. SNVs with predictive power may stratify patient populations according to likelihood of responding to treatment, therefore enabling more efficient identification of beneficial strategies for pain management and improved resource utilisation.