The European journal of surgery = Acta chirurgica
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Randomized Controlled Trial Comparative Study Clinical Trial
Prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. A prospective randomized study of metoclopramide and transdermal hyoscine.
To compare the antiemetic effects of metoclopramide and hyoscine in patients after laparoscopic cholecystectomy. ⋯ There was a high incidence of nausea and vomiting after laparoscopic cholecystectomy even after treatment with metoclopramide. Further measures are indicated, particularly for women.
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Clinical Trial Controlled Clinical Trial
Dose response profiles of human growth hormone in subcutaneous wound chambers in rats.
To investigate dose response profiles of human growth hormone in soft connective tissue healing when it is given locally in subcutaneous wound chambers. ⋯ The clinical use of topical growth hormone in wound healing may be complicated by the relatively narrow therapeutic interval.
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To find out if intramedullary nailing affects lung function and microvascular permeability whether or not the lung is already injured; if so whether a different method of fixation would diminish the effect; and are the pathogenetic changes related to mechanisms known to precipitate adult respiratory distress syndrome? ⋯ Intramedullary nailing causes additional damage to lungs after lung damage and haemorrhagic shock in sheep. This can be avoided if (in the presence of additional injuries) alternative methods are used.
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After major operations, hypoxaemia is common in the late postoperative period in the surgical ward. Recent studies of humans after major operations showed that such hypoxaemia may be related to the development of myocardial ischaemia and cardiac arrhythmias, even in patients with no preoperative signs or symptoms of coronary artery disease. ⋯ Finally, mental confusion and surgical delirium may be related to inadequate arterial oxygenation during the late postoperative period. Hypoxaemia may therefore prove to be a risk factor in the late postoperative period, and further studies are needed to clarify its pathogenesis and rational treatment.