The American journal of gastroenterology
-
Am. J. Gastroenterol. · Apr 2006
Randomized Controlled TrialInfluence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways.
Motilin agonists are strong gastroprokinetics, but their impact on symptoms in delayed gastric emptying has been disappointing. It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated. ⋯ Administration of motilin causes a contraction of the proximal stomach in humans and increases meal-induced satiety. The effect of motilin is atropine-resistant and involves a direct muscular pathway or a non-cholinergic neural pathway.
-
Am. J. Gastroenterol. · Feb 2006
Randomized Controlled Trial Multicenter StudyThe gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases.
While traditional nonsteroidal antiinflammatory drugs (t-NSAIDs) are relatively contraindicated in patients with inflammatory bowel disease (IBD) for fear of disease aggravation, controlled clinical trials showed that cyclo-oxygenase-2 inhibitors have fewer gastrointestinal side effects than the t-NSAIDs. Etoricoxib is a new antiinflammatory inhibitor that has high Cox-2 selectivity. ⋯ Etoricoxib therapy is safe and beneficial in most patients with IBD treatment with etoricoxib was not associated with exacerbation of the underlying IBD- and GI-related complications.
-
Am. J. Gastroenterol. · Jan 2006
Randomized Controlled Trial Multicenter Study Comparative StudyRisk factors for post-ERCP pancreatitis: a prospective multicenter study.
Pancreatitis is the most common and serious complication of diagnostic and therapeutic ERCP. The aim of this study is to examine the potential patient- and procedure-related risk factors for post-ERCP pancreatitis in a prospective multicenter study. ⋯ This study emphasizes the role of patient factors (age, SOD, prior history of post-ERCP pancreatitis) and technical factors (number of PD injections, minor papilla sphincterotomy, and operator experience) as the determining high-risk predictors for post-ERCP pancreatitis.
-
Am. J. Gastroenterol. · Dec 2005
Randomized Controlled Trial Comparative StudyPremedication with intravenous ketorolac trometamol (Toradol) in colonoscopy: a randomized controlled trial.
We conducted a prospective double-blinded placebo-controlled randomized trial to investigate the effect of ketorolac trometamol (KT) administered intravenously as premedication in colonoscopy. ⋯ Premedication with IV KT (Toradol) improves pain control during colonoscopy with no associated serious complications.
-
Am. J. Gastroenterol. · Nov 2005
Randomized Controlled Trial Comparative StudyUrgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial.
We hypothesized that early intervention in patients with lower gastrointestinal bleeding (LGIB) would improve outcomes and therefore conducted a prospective randomized study comparing urgent colonoscopy to standard care. ⋯ Although urgent colonoscopy identified a definite source of LGIB more often than a standard care algorithm based on angiography and expectant colonoscopy, the approaches are not significantly different with regard to important outcomes. Thus, decisions concerning care for patients with acute LGIB should be based on individual experience and local expertise.