International journal of clinical pharmacology research
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Int J Clin Pharmacol Res
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Int J Clin Pharmacol Res · Jan 1993
Randomized Controlled Trial Comparative Study Clinical TrialPost-operative analgesia with tramadol: a controlled study compared with an analgesic combination.
The analgesic action of tramadol in the post-operative period was compared with that of an analgesic combination (Nisidin) in a sample of 60 patients (31 male, 29 female) aged between 20 and 70 years undergoing surgical operations on the abdomen involving opening of the peritoneum. The study was carried out according to a controlled and randomized experimental design. ⋯ Local and general safety were good in both groups, and respiratory and heart rates did not undergo clinically significant modifications. In conclusion, tramadol proves to be particularly indicated in the treatment of post-operative pain, given that it has analgesic action combined with good local and general safety.