Panminerva medica
-
By April 25, 2020, the outbreak of COVID-19 caused 2,719,897 confirmed cases and 18,7705 deaths globally, remarkably more than severe acute respiratory syndrome (SARS) (8273 cases, 775 deaths) and middle east respiratory syndrome (MERS) (1139 cases, 431 deaths) in 2003 and 2013, respectively. Gynecology is a specialty department with many critical and severe patients. Consequently, it is of preeminent importance to formulate the in-patient management process. ⋯ To effectively minimize nosocomial infections during the COVID-19 pandemic period, our department implemented a novel prevention strategy based on the ward redesign and partition management. With this model, our department effectively protected the safety and health of patients and medical care staff from cross and nosocomial infection in the hospital. Now we would like to share the experience and strategies we implemented as following.
-
Meta Analysis
Effect of metformin use on the risk and prognosis of ovarian cancer: an updated systematic review and meta-analysis.
Emerging evidence suggests that metformin has a potential antitumor effect both in vitro and in vivo. Increasing epidemiological studies indicate that diabetic patients receiving metformin therapy have lower incidences of cancer and have better survival rates. However, there are limited and inconsistent studies available about the effect of metformin therapy on ovarian cancer (OC). Thus, we conducted this meta-analysis to study the effect of metformin therapy on OC. Meanwhile, we systematically reviewed relevant studies to provide a framework for future research. ⋯ The use of metformin can potentially reduce the risk of OC among diabetics, and it also can significantly improve PFS and OS in patients with OC. A further large clinical investigation would be needed to adopt our finding in practice, however, our systematic review provides an insight for future study designs.