Acta anaesthesiologica Sinica
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Acta Anaesthesiol. Sin. · Sep 1995
Randomized Controlled Trial Clinical TrialMagnesium sulfate has negligible effect on middle cerebral artery blood flow velocity in response to endotracheal intubation.
Pretreatment of magnesium sulfate (MgSO4) attenuates pressor response associated with endotracheal intubation. Vasodilating effect of MgSO4 may increase cerebral blood flow, which upsets the known benefit to cardiovascular hemodynamic. In the present study, we evaluated the effect of MgSO4 on the changes of cerebral blood flow in response to endotracheal intubation. ⋯ Our results suggest that MgSO4 appeared to have negligible effects on cerebral blood flow and hemodynamics in response to tracheal intubation. Its attenuating effect on pressor response induced by endotracheal intubation might be over emphasized.
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Acta Anaesthesiol. Sin. · Sep 1995
Randomized Controlled Trial Clinical TrialThe effect of intrathecal bupivacaine with combined fentanyl in cesarean section.
The use of neuraxial opioids has gained popularity over the last few years; they may augment the analgesia produced by the local anesthetic through direct binding with the specific spinal receptors. Morphine, a lipophobic opioid, may not be optimal as an intrathecal drug for intraoperative analgesia because of its slow onset. The lipophilic opioid, fentanyl for instance, if administered intrathecally, its onset is fast and many of its merits by virtue of its lipophilic property may be seen intraoperatively. ⋯ The combination of bupivacaine with a dose of fentanyl as low as 7.5 micrograms did not produce actual clinical effects. As the dose of fentanyl was increased to 12.5 micrograms or 15 micrograms the quality of surgical analgesia was better and the postoperative analgesia lasted longer. It seemed that the clinical effect might reach its ceiling at the dose of 12.5 micrograms. Pruritus was the most common side effect, but it was mild.
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Acta Anaesthesiol. Sin. · Jun 1995
Randomized Controlled Trial Clinical TrialIntravenous tenoxicam reduces dose and side effects of PCA morphine in patients after thoracic endoscopic sympathectomy.
Among surgical modalities for treatment of palmar hyperhidrosis, endoscopic sympathectomy is the most popular choice in recent years. After surgery, the major complaint was anterior chest pain. This study was conducted to evaluate the analgesic efficacy and side effects of tenoxicam (a thienothiazine derivative) in combination with patient-controlled analgesia (PCA) using morphine in patients who received thoracic endoscopic sympathectomy. ⋯ Tenoxicam may be an effective adjuvant to PCA morphine for postoperative pain control. This combination reduces the total consumption of PCA morphine with less side effects.
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Acta Anaesthesiol. Sin. · Jun 1995
Randomized Controlled Trial Clinical TrialAnalgesic effect of intra-articular morphine after arthroscopic knee surgery in Chinese patients.
Small or systematically inactive doses of morphine administered into the knee joint during intra-articular surgery can elicit potent and long-lasting postoperative analgesia. The reports studied in USA, Spain, UK, Germany, Ireland, etc. showed that intra-articular morphine 0.5-5 mg could produce a significant analgesic effect with an onset time of 0-6 h after administration and a duration of 24-48 h. However, there were no available data about the Chinese people; therefore, this study was designed to collect the data regarding this subject. ⋯ We concluded that intra-articular morphine 1 mg in Chinese patients could provide an effective and long-lasting analgesic effect, which was quite similar with the result presented in other races.
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Acta Anaesthesiol. Sin. · Mar 1995
Randomized Controlled Trial Clinical Trial[The thermoregulatory threshold during surgery with propofol-nitrous oxide anaesthesia].
Thermoregulatory responses are thought to be drastically suppressed by general anesthesia. In previous studies, it was shown that halothane, isoflurane and fentanyl-N2O combination decrease the threshold of vasoconstriction in general anesthesia. Propofol is a recently introduced intravenous anesthetic. The thermoregulatory threshold of its administration during surgery has not been quantified. ⋯ General anesthesia with propofol/N2O during surgery drastically inhibits thermoregulatory vasoconstriction. This effect should also be noted during long-term use of propofol (e.g. ICU-sedation).