Scandinavian journal of gastroenterology. Supplement
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Scand. J. Gastroenterol. Suppl. · Jan 1984
Enhancement of duodenal and jejunal ulceration by histamine-induced gastric hypersecretion in dogs with diversion of duodenal contents.
In a previous investigation deviation of duodenal contents protected rats significantly from the development of peptic ulceration under maximal acid secretion. We have now assessed the effect of diversion of duodenal contents in dogs submitted to the same operative procedure under histamine-induced hypersecretion. Six mongrel dogs underwent the following procedure: A two cm duodenal segment was left adjacent to the intact pylorus, proximal jejunum anastomosed to this segment and a Roux-en-Y duodeno-jejunostomy performed. ⋯ It was concluded that the diversion of duodenal contents enhanced ulcer formation in dogs and that the model mimicked a Zollinger-Ellison Syndrome. Ulceration occurred in transitional or jejunal type of duodenal mucosa. No gastric lesions were found and this suggests that the diversionary procedure was an effective means of preventing bile from reaching the gastric mucosa.