Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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Randomized Controlled Trial
Abnormal cortical activation in females with acute migraine: a magnetoencephalography study.
The objective of this study was to investigate functional abnormalities of the brain in females with migraine using magnetoencephalography (MEG) and a finger-tapping task. ⋯ These findings may help to identify neurophysiological biomarkers for studying mechanisms of migraine, and may facilitate to develop new therapeutic strategies for migraine by alterations in cortical excitability.
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Joint immobilization has previously been shown to modulate corticospinal excitability. The present study investigated changes in the excitability of distinct fractions of the corticospinal pathway by means of conditioning the H-reflex with transcranial magnetic stimulation (TMS) of the primary motor cortex (Hcond). This method allows assessment of transmission in fast (monosynaptic) and slow(er) (polysynaptic) corticospinal pathways. ⋯ It is particularly interesting that fast corticospinal projections were unaffected as these are involved in controlling many, if not most, movements in humans.
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The purpose of this study was to investigate the effect of anodal transcranial direct-current stimulation (tDCS) applied over the primary motor (M1) or the primary somatosensory (S1) cortices on somatosensory evoked magnetic fields (SEFs) following median nerve stimulation. ⋯ We demonstrated anodal tDCS applied over M1 or S1 can modulate somatosensory processing and components of SEFs, confirming the hypothesis for locally distinct generators of the P35m and P60m sources.