Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
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Multicenter Study
Drotrecogin alfa's impact on intensive care workload in real life practice: a propensity score approach.
To estimate the impact of drotrecogin alfa (DA) on intensive care workload in an observational study while illustrating the use of propensity score (PS) matching to control for recruitment bias. ⋯ We found a significant effect of DA on ICU workload with both standard methods of adjustment and PS matching. This effect appears to be mainly due to DA's effect on bleeding events. The analysis illustrated the usefulness of PS methods in the analysis of observational data, as it leads to conclusions similar to the traditional multivariate regression approaches while avoiding making too many adjustments, allowing focusing on the treatment effect.
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Multicenter Study Comparative Study Clinical Trial
Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients.
To examine the cost-effectiveness of using recombinant human erythropoietin (rHuEPO) to reduce red blood cells (RBC) transfusions in intensive care unit (ICU) patients. ⋯ rHuEPO appears to be cost-effective for reducing RBC transfusions in heterogeneous ICU populations, assuming RBC transfusions increase the risk of nosocomial bacterial infections.