Deutsche medizinische Wochenschrift
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Dtsch. Med. Wochenschr. · Jan 2025
Case Reports[Arthropathy as the first manifestation of undiagnosed hemochromatosis: a case report on an unusual course].
A 54-year-old man presented with increasing arthralgia and swelling of the metacarpophalangeal (MCP) joints II and III for approximately 2 years. He also reported morning stiffness and joint pain in both knees and feet. Both MCP joints II and III and the proximal interphalangeal joints II and III were tender without visible swelling. ⋯ During the hospital stay, the patient received physical and occupational therapy. Hepatology specialists will manage further treatment at a university center, and the outcome remains to be seen. Symmetrical involvement of the MCP joints II and III should raise suspicion of hemochromatosis.
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Dtsch. Med. Wochenschr. · Jan 2025
[Chronic Kidney Disease: epidemiology, implications for clinical practice and equations for diagnosis].
The article is based, among other things, on the updated KDIGO guideline for the evaluation and management of chronic kidney disease, which was published in Kidney International in March 2024. Chronic kidney disease is one of the most common chronic diseases, with a prevalence of around 10%, not least due to demographic ageing. The incidence of chronic kidney disease is approximately twice that of diabetes and approximately 20 times higher than that of cancer. ⋯ A better understanding of age- and gender-specific differences means that personalized therapy approaches are becoming increasingly important. Clinicians should be aware of the limitations of the endogenous biomarkers creatinine and cystatin C for determining GFR. For Germany, the equations of the European Kidney Function Consortium (EKFC) are recommended for estimating GFR.