Deutsche medizinische Wochenschrift
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A new classification of patients with diabetes mellitus into so-called clusters can be used to assess the risk of developing diabetic nephropathy. Up to date treatment of patients with diabetic nephropathy includes not only glycemic control, but focuses on a holistic approach with prevention of (progression of) secondary diabetic complications and reduction of the patient's cardiovascular mortality. ⋯ Adjustment of drug therapy is no longer based on antihyperglycemic effects alone, but takes into account inhibition of progression of nephropathy and cardiac risk, as well as support of body weight control. For this purpose, in addition to RAAS inhibitors from the field of antihypertensives, the antidiabetic classes of SGLT2 inhibitors and GLP-1 receptor agonists as well as the non-steroidal aldosterone antagonist finerenone are now available.
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Our understanding of the molecular basis of the development and progression of malignant lymphoma has significantly improved over the last decades leading to the identification of genetic alterations with proven prognostic impact on the clinical course of the disease, such as TP53 mutations in MCL. This deepened molecular understanding sets the basis for the current rapid development regarding targeted and immuno-based therapies, offering individualized, risk-adapted treatment strategies in our near future with the potential to further improve patient care. ⋯ For such high-risk patients, further optimized and individualized therapeutic strategies are highly warranted. This article summarizes new findings regarding tumor biology and actual developments expanding the therapeutic landscape of DLBCL and MCL.
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TTS is an acute heart failure syndrome that usually affects postmenopausal women. The Syndrome is often preceded by an emotional or physical trigger. TTS strongly resembles acute myocardial infarction from a clinical standpoint and also exhibits ECG changes in the same proportion. ⋯ Therapy is based on the hemodynamic state and the presence of left ventricular outflow tract obstruction or cardiogenic shock. TTS has a comparable mortality to acute myocardial infarction. Pathophysiologically, the activation of the brain-heart axis with acute catecholamine storm seems to inherit a central role.
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Drug-induced cardiovascular side effects have a significant impact on morbidity and mortality. The demographic change and improved long-term survival particularly in cancer patients have caused an increasing number of affected patients, hence emphasizing the importance of the best possible treatment of such complications. This article gives an overview of classic and modern groups of substances with cardiotoxic effects and summarizes the principles of diagnostics and therapy. ⋯ In addition to specific cancer therapies, accompanying measures such as blood transfusions in patients with hematologic diseases can also lead to severe cardiovascular complications. In the last section, we classify important features and therapeutic approaches in cardiac involvement of transfusion-related hemochromatosis. A good knowledge of the characteristics of specific cardiovascular side effects can help to improve the management of affected patients.
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Suicidality is a complex phenomenon. Helping professions are likely to be confronted with this issue. The article aims to provide information about suicidality in the context of mental illnesses and prevention, but above all to provide recommendations.