The heart surgery forum
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The heart surgery forum · Jan 2007
Good recovery after nontransthoracic cardiopulmonary bypass in rats.
Cardiopulmonary bypass (CPB) has been shown to be associated with systemic inflammatory response leading to postoperative organ dysfunction. Unwanted side effects of CPB are well known but poorly understood due to the absence of a stable recovery animal model that is easy to handle and reduces experiment cost and time. The purpose of this study was to establish a good recoverable rat model of CPB to study the pathophysiology of these potential complications. ⋯ The rat model of CPB can in principle simulate the clinical setting of human CPB. The non-transthoracic model is easy to establish and is associated with excellent recovery. This reproducible model may open the field for various studies on the pathophysiological process of CPB and systemic ischemia-reperfusion injury in vivo.
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The heart surgery forum · Jan 2007
Randomized Controlled TrialPredictive significance of plasma levels of interleukin-6 and high-sensitivity C-reactive protein in atrial fibrillation after coronary artery bypass surgery.
Postoperative atrial fibrillation (AF) plays a major role in the determination of hemodynamic deterioration and can be associated with cardiovascular events after coronary artery surgery. Elevated interleukin (IL)-6 and C-reactive protein (CRP) levels in patients with AF suggest a role of inflammation in the pathogenesis of AF. We conducted a study to investigate the correlation between postoperative AF and IL-6 and high-sensitivity CRP (hsCRP). ⋯ Elevated IL-6 and hsCRP levels in patients with postoperative AF suggest inflammatory components have a role of in the pathogenesis of AF.
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The heart surgery forum · Jan 2007
Randomized Controlled TrialThe effects of isoflurane, sevoflurane, and desflurane anesthesia on neurocognitive outcome after cardiac surgery: a pilot study.
Inhalation anesthetics such as isoflurane, sevoflurane, and desflurane are widely used in clinical practice; however, there is no study for comparing these drugs in cardiac surgery with respect to postoperative cognitive outcome and S100 beta protein (S100 BP) levels. In this study, we evaluated the effect of sevoflurane, isoflurane, and desflurane anesthesia on neuropsychological outcome and S100 BP levels in patients undergoing coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB). ⋯ Our study suggests that isoflurane is associated with better neurocognitive functions than desflurane or sevoflurane after on-pump CABG. Sevoflurane seems to be associated with the worst cognitive outcome as assessed by neuropsychologic tests, and prolonged brain injury as detected by high S100 BP levels was seen with desflurane.