Epilepsy & behavior : E&B
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Epilepsy & behavior : E&B · Jul 2008
Randomized Controlled Trial Clinical TrialAcceptance and Commitment Therapy and yoga for drug-refractory epilepsy: a randomized controlled trial.
There is a need for controlled outcome studies on behavioral treatment of epilepsy. The purpose of this study was to evaluate Acceptance and Commitment Therapy (ACT) and yoga in the treatment of epilepsy. ⋯ The results of this study suggest that complementary treatments, such as ACT and yoga, decrease seizure index and increase quality of life.
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Epilepsy & behavior : E&B · May 2007
Randomized Controlled Trial Comparative Study Clinical TrialSlight improvement in mood and irritability after antiepileptic drug withdrawal: a controlled study in patients on monotherapy.
Most antiepileptic drugs (AEDs) are considered to have effects on mood and to be effective in a number of affective disorders. There are, however, conflicting reports in the literature with respect to the psychotropic properties of AEDs. Many of the studies have a number of methodological problems, and much uncertainty still exists regarding the behavioral and mood effects of AEDs. The aim of this study was to assess, in a randomized, double-blind, placebo-controlled study of seizure-free patients with epilepsy, the effect of withdrawal of AEDs in patients on monotherapy on measures of mood and behavior. ⋯ The results suggest that seizure-free patients with epilepsy on monotherapy can obtain a slight improvement in symptoms characteristic of depression and irritability if they discontinue treatment with AEDs. The described changes are limited, and the functional impact is of uncertain significance.
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Epilepsy & behavior : E&B · Apr 2004
Randomized Controlled Trial Comparative Study Clinical TrialComparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children.
Midazolam, a water-soluble benzodiazepine, is usually given intravenously in status epilepticus. The aim of this study was to determine whether intranasal midazolam is as safe and effective as intravenous diazepam in the treatment of acute childhood seizures. Seventy children aged 2 months to 15 years with acute seizures (febrile or afebrile) admitted to the pediatric emergency department of a general hospital during a 14-month period were eligible for inclusion. ⋯ No significant side effects were observed in either group. Although intranasal midazolam was as safe and effective as diazepam, seizures were controlled more quickly with intravenous diazepam than with intranasal midazolam. Intranasal midazolam can possibly be used not only in medical centers, but also in general practice and at home after appropriate instructions are given to families of children with recurrent seizures.