Pain medicine : the official journal of the American Academy of Pain Medicine
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Neuropathic pain is an area of unmet clinical need. The objective of this study was to define the pharmacokinetics, oral bioavailability, and efficacy in rats of small molecule antagonists of the angiotensin II type 2 receptor (AT₂R) for the relief of neuropathic pain. ⋯ The small molecule AT₂R antagonist, EMA401, is in clinical development as a novel analgesic for the relief of neuropathic pain.
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To compare health care resource utilization before and after minimally invasive lumbar decompression (MILD) procedure. ⋯ Not only is MILD a reliable method to treat LSS, MILD also appears to reduce the consumption of limited health care resources.
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We elaborated the rat hippocampi in order to assess for central nervous system changes following a peripheral neuropathic injury. ⋯ Our results showed that the peripheral nerve injury altered rat hippocampal miRNA.