Pain medicine : the official journal of the American Academy of Pain Medicine
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Several reports in literature have identified sensitization as a possible basis for the enhanced pain reactions associated with osteoarthritis (OA). The aim of this current systematic review is to summarize functional and structural brain changes associated with surrogate sensitization parameters assessed in patients with OA-related pain. ⋯ This review shows conflicting evidence for structural and functional neuroplastic brain changes related to sensitization proxies in patients with OA.
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Meta Analysis
Repetitive transcranial magnetic stimulation for fibromyalgia patients: A Systematic Review with Meta-Analysis.
Fibromyalgia is a poorly understood pain syndrome. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation therapy and is commonly applied for the management of fibromyalgia. However, controversy about its efficacy remains. Therefore, a meta-analysis was conducted to evaluate the effectiveness of rTMS for fibromyalgia syndrome. ⋯ This study demonstrated that rTMS relieved pain and enhanced the quality of life of patients with fibromyalgia; however, on the basis of current reports, it did not improve anxiety, depression, or other symptoms.