Annals of allergy
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Fourteen patients with hay fever were treated with one intramuscular injection of methylprednisolone acetate, which gave satisfactory symptomatic relief for three weeks. Their hypothalamic-pituitary-adrenal function was moderately but significantly suppressed for three weeks but became normal again after four weeks.
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A group of 25 honey bee venom allergic patients were treated with commercial honey bee venom at a monthly maintenance dose of 100 micrograms for approximately one year. At the end of one year 24 patients were intentionally challenged and one was accidentally challenged. Three patients experienced significant systemic reactions to challenge and three experienced minor reactions. ⋯ The diagnostic efficiency of the criteria used for assessing protection was 0.96. The only non-correlating case was classifying a single nonreactor as at risk. No patients were misclassified as protected.
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Case Reports Clinical Trial Controlled Clinical Trial
Mechanism for the diluent response in asthma.
To investigate the mechanism underlying the airway response to diluent challenge, three adult asthmatic patients who were known to be reactive to inhaled diluent were studied. Airway response as measured by conventional pulmonary function testing was measured under the conditions of time, inhalation of room air, diluent and placebo. ⋯ The third subject reacted primarily to the diluent and not to time, room air or normal saline. Two of the three patients were placebo responders.