BJOG : an international journal of obstetrics and gynaecology
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Randomized Controlled Trial Multicenter Study
The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months.
To assess the long-term effects of in utero exposure to magnesium sulphate for children whose mothers had pre-eclampsia. ⋯ The lower risk of eclampsia following prophylaxis with magnesium sulphate was not associated with a clear difference in the risk of death or disability for children at 18 months.
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Two recent studies indicate an increased risk of stillbirth in the pregnancy that follows a pregnancy delivered by caesarean section. In this study, we report an analysis designed to test the hypothesis that delivery by caesarean section is a risk factor for explained or unexplained stillbirth in any subsequent pregnancy. We also report on the proportion of stillbirths in our study population, which may have been attributable to previous delivery by caesarean section. ⋯ Pregnancies in women following a pregnancy delivered by caesarean section are at an increased risk of stillbirth. In our study, the risk appears to be mainly concentrated in the subgroup of explained stillbirths. However, there are sufficient inconsistencies in the developing literature about stillbirth risk that further research is needed.
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Randomized Controlled Trial Multicenter Study
The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2 years.
The aim of this study was to assess long-term effects for women following the use of magnesium sulphate for pre-eclampsia. ⋯ The reduction in the risk of eclampsia following prophylaxis with magnesium sulphate was not associated with an excess of death or disability for the women after 2 years.
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Randomized Controlled Trial Multicenter Study
Magnesium sulphate given before very-preterm birth to protect infant brain: the randomised controlled PREMAG trial*.
To evaluate whether magnesium sulphate (MgSO(4)) given to women at risk of very-preterm birth would be neuroprotective in preterm newborns and would prevent neonatal mortality and severe white-matter injury (WMI). ⋯ Although our results are inconclusive, improvements of neonatal outcome obtained with MgSO(4) are of potential clinical significance. More research is needed to assess the protective effect of MgSO(4) alone or in combination with other neuroprotective molecules.
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Multicenter Study
Internal iliac artery ligation for arresting postpartum haemorrhage.
To study the role of internal iliac artery ligation (IIAL) in arresting and preventing postpartum haemorrhage (PPH). ⋯ IIAL is useful in the treatment and prevention of PPH from any cause. Early resort to IIAL effectively prevents hysterectomy in women with atonic PPH. In traumatic PPH, IIAL facilitates hysterectomy or repair as indicated and prevents reactionary haemorrhage.