Current opinion in allergy and clinical immunology
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Curr Opin Allergy Clin Immunol · Aug 2004
ReviewCough and angioedema from angiotensin-converting enzyme inhibitors: new insights into mechanisms and management.
Angiotensin-converting enzyme inhibitors are widely prescribed for hypertension and heart failure. These drugs are commonly associated with cough, and are less commonly associated with angioedema, which may be potentially life threatening. This review describes data that extend our understanding of the mechanisms of these reactions, and provides guidance about clinical management. ⋯ Although data are incomplete, it appears that angiotensin-converting enzyme inhibitors cause cough and angioedema through a cascade of effects that begins with the accumulation of kinins, and then involves arachidonic acid metabolism and nitric oxide generation. Most patients who develop either cough or angioedema from angiotensin-converting enzyme inhibitors can tolerate angiotensin-II receptor blocking agents.
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Anaphylaxis due to ant sting is increasingly being recognized as a significant problem. Severe allergic reactions to ants are well described in the south-eastern United States, but have only been recognized in recent years as being important in other parts of the world. There are many different ant species and their distribution around the world varies. The purpose of this review is to familiarize the reader with the epidemiology and clinical characteristics of ant allergy in Asia and Australia. ⋯ The study of ant allergy in Asia is in its infancy. Clinicians in Asia need to be aware of ant stings as a cause of severe allergic reactions. Certain species that cause allergic reactions are unique to Asia and Australia and deserve further research. The allergens in the venom of the different ant species need to be identified. We should aim for improved understanding of the epidemiology of ant-sting anaphylaxis, formulation of better diagnostic tests and possibly the introduction of immunotherapeutic strategies.
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Curr Opin Allergy Clin Immunol · Dec 2003
ReviewPrevention of anaphylaxis with ant venom immunotherapy.
Worldwide, eight genera of ants have been associated with sting allergy. Until recently only whole ant body extracts have been used for immunotherapy. The purpose of this review is to examine recent advances in the understanding of ant venom allergy and treatment using venom immunotherapy. ⋯ Ant venom immunotherapy is feasible and highly efficacious. However, the limited geographical distribution of each species presents a major challenge to making venom extracts available for clinical use.
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Curr Opin Allergy Clin Immunol · Aug 2003
ReviewUse of epinephrine in the treatment of anaphylaxis.
This paper is intended to review recent literature that impacts the use of epinephrine in the therapy of anaphylaxis. ⋯ Several major themes have emerged from this review of the recent literature. The finding that the intramuscular route of administration for epinephrine is superior has now been recognized by the guidelines, and because the site of choice has been found to be the lateral aspect of the thigh, the needle used for injection must be long enough to penetrate the vastus lateralis muscle. The reasons for the underutilization of epinephrine in the treatment of anaphylaxis are also discussed. Other important findings include the fact that outdated EpiPens can usually be administered safely, and alternative routes of administration, which may be more acceptable to patients, may be on the horizon as a result of preliminary studies assessing the administration of sublingual epinephrine by wafer. Finally, it is now understood that epinephrine prescription data may be one of our best tools to study the epidemiology and incidence of anaphylactic episodes.
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Curr Opin Allergy Clin Immunol · Apr 2002
ReviewUtilization of pulmonary function measurements in the assessment of occupational asthma.
Lung function assessments that include spirometry and bronchial responsiveness are now often coupled to immunological assessment and an evaluation of inflammation in the investigation of occupational asthma. For diagnostic purposes, evidence points out that specific inhalation challenges are the gold standard, as previously suspected. In the epidemiological setting, both spirometry and bronchial responsiveness are feasible and safe. The role of lung function assessments in surveillance programmes is still open to discussion.