Veterinary anaesthesia and analgesia
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Randomized Controlled Trial
The use of different doses of metamizol for post-operative analgesia in dogs.
To evaluate the post-operative analgesic effect of metamizol (dipyrone) administered intravenously at three different doses (15 mg kg(-1), 25 mg kg(-1) and 35 mg kg(-1)) compared to placebo in dogs undergoing ovariohysterectomy. ⋯ Metamizol administered intravenously at 25 or 35 mg kg(-1) can provide adequate post-operative analgesia in bitches undergoing ovariohysterectomy.
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Randomized Controlled Trial
The effect of ketamine on the MACBAR of sevoflurane in dogs.
To determine the effect of intravenous ketamine on the minimum alveolar concentration of sevoflurane needed to block autonomic response (MAC(BAR)) to a noxious stimulus in dogs. ⋯ Ketamine at clinically relevant doses of 12.5, 25, and 50 μg kg(-1) minute(-1) decreased sevoflurane MAC(BAR), although the reduction was neither dose-dependent nor linear.
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To determine the magnitude and duration of sevoflurane minimum alveolar concentration (MAC) reduction following a single intravenous (IV) dose of methadone in cats. ⋯ Intravenous methadone (0.3 mg kg(-1)) significantly decreased MAC of sevoflurane in cats but the effect was short-lived.
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Randomized Controlled Trial
Twitch potentiation: a potential source of error during neuromuscular monitoring with acceleromyography in anesthetized dogs.
To measure twitch potentiation (the staircase phenomenon) in anesthetized dogs, and assess its relevance during neuromuscular monitoring with acceleromyography (AMG). ⋯ T(1) increased significantly during 20 minutes of uninterrupted TOF stimulation in the absence of NMB, establishing that twitch potentiation occurs in anesthetized dogs. With no time for potentiation, T(1) increased during the course of recovery from NMB; this phenomenon introduces a bias in T(1) measurements and could affect studies reporting potency and duration of NMB based on T(1) or single twitches. TOFR was unaltered by potentiation emphasizing its clinical usefulness for excluding post-operative residual NMB.
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Comparative Study
Quantitative and qualitative comparison of three scoring systems for assessing recovery quality after general anaesthesia in horses.
To assess the reproducibility and repeatability of two commonly used recovery quality scoring systems and compare them with those of a novel system based on a greater number of objective criteria. ⋯ The systems examined showed reliability and reproducibility but practicality and simplicity of use appeared to be inextricably linked with imprecision. Further work is required to produce a suitable recovery quality scoring system.