Veterinary anaesthesia and analgesia
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Randomized Controlled Trial
Influence of ketamine or xylazine supplementation on isoflurane anaesthetized horses--a controlled clinical trial.
To determine the influence of ketamine or xylazine constant rate infusions on isoflurane requirements, cardiovascular parameters and quality of anaesthesia in horses undergoing elective surgery. ⋯ All three protocols provided good clinical anaesthesia with clinically acceptable cardiovascular effects.
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Randomized Controlled Trial
Chronotropic effect of propofol or alfaxalone following fentanyl administration in healthy dogs.
To compare the effect of alfaxalone and propofol on heart rate (HR) and blood pressure (BP) after fentanyl administration in healthy dogs. ⋯ Following fentanyl administration, HR decreases more frequently when propofol rather than alfaxalone is used as induction agent. However, given the high individual variability and the small change in predicted HR (-7.7 beats per minute after propofol), the clinical impact arising from choosing propofol or alfaxalone is likely to be small in healthy animals. Further studies in dogs with myocardial disease and altered haemodynamics are warranted.
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Clinical Trial
Pharmacokinetic-pharmacodynamic modelling of intravenous buprenorphine in conscious horses.
Describe the pharmacokinetics of buprenorphine and norbuprenorphine in horses and to relate the plasma buprenorphine concentration to the pharmacodynamic effects. ⋯ The suitability of the use of buprenorphine for peri-operative analgesia in the horse is supported by the present study.
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To evaluate the incidence of myoclonus (involuntary movements during anaesthesia, unrelated to inadequate hypnosis or analgesia, and of sufficient severity to require treatment) in dogs anaesthetized with a TIVA of propofol with or without the use of fentanyl. ⋯ This study shows that 1.2% of dogs, undergoing TIVA with propofol with or without fentanyl administration, developed myoclonus, which required to be, and were treated successfully pharmacologically. The cause of this phenomenon is yet to be determined.