Veterinary anaesthesia and analgesia
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Randomized Controlled Trial
Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs.
To compare the incidence of pain during injection of three intravenous induction agents in dogs. ⋯ No dogs reacted to saline or Drug(A,) thus Drug(A) was excluded from analysis. Pain on injection occurred in six dogs (20%) with Drug(PC) and one dog (3.3%) with Drug(P). Pain was severe in four dogs with Drug(PC). Drug(P) resulted in a trend for reduced risk of pain compared to Drug(PC) (p = 0.076, odds ratio [confidence intervals] 0.14 [0.027-0.86]). Both propofol formulations resulted in greater risk of excitation than Drug(A) (p = 0.0003, odds ratio 4.5 [1.86-10.90]). Induction agent was associated with pain, whilst catheter placement was not. One dog developed facial oedema and one other dog skin necrosis adjacent to the catheter site following Drug(PC.) The study was terminated early due to ethical concerns about the severity of reactions with Drug(PC). conclusions and clinical relevance: Drug(PC) was associated with clinically relevant moderate to severe pain behaviour whilst Drug(A) and Drug(P) were not.
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To investigate the changes in serum enzymes considered as biochemical indicators of hepatobiliary function in dogs following 5 hours of anaesthesia with isoflurane (ISO) or sevoflurane (SEVO). ⋯ Both ISO and SEVO, at concentrations used for clinical anaesthesia, produce transient moderate effects on some hepatobiliary enzyme concentrations in dogs.
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Randomized Controlled Trial
Evaluation of the quality of the recovery after administration of propofol or alfaxalone for induction of anaesthesia in dogs anaesthetized for magnetic resonance imaging.
To compare the quality of the recovery when propofol or alfaxalone were administered for the induction of anaesthesia in dogs undergoing neurological diagnostic procedures. ⋯ Greater attention to the recovery environment may be advisable when using alfaxalone for induction of anaesthesia where minimal premedication has been used. Further sedation in recovery may be required.
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Randomized Controlled Trial Comparative Study
Comparison of three techniques for paravertebral brachial plexus blockade in dogs.
To compare success and complication rates, based on staining of nerves and other structures, among three techniques of paravertebral brachial plexus blockade (PBPB) in dogs. ⋯ The use of more advanced techniques for PBPB in dogs is not justified according to this study. Clinical significance of the complications encountered in this study should be evaluated.
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Randomized Controlled Trial
Minimum infusion rate and hemodynamic effects of propofol, propofol-lidocaine and propofol-lidocaine-ketamine in dogs.
To evaluate the effects of a constant rate infusion (CRI) of lidocaine alone or in combination with ketamine on the minimum infusion rate (MIR) of propofol in dogs and to compare the hemodynamic effects produced by propofol, propofol-lidocaine or propofol-lidocaine-ketamine anesthesia. ⋯ Lidocaine-ketamine, but not lidocaine alone, reduced the MIR of propofol in dogs. Neither lidocaine nor lidocaine in combination with ketamine attenuated cardiovascular depression produced by a continuous rate infusion of propofol.