The lancet oncology
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The lancet oncology · Mar 2015
Randomized Controlled Trial Multicenter StudyHigh-dose radiotherapy with short-term or long-term androgen deprivation in localised prostate cancer (DART01/05 GICOR): a randomised, controlled, phase 3 trial.
The optimum duration of androgen deprivation combined with high-dose radiotherapy in prostate cancer remains undefined. We aimed to determine whether long-term androgen deprivation was superior to short-term androgen deprivation when combined with high-dose radiotherapy. ⋯ Spanish National Health Investigation Fund, AstraZeneca.
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The lancet oncology · Mar 2015
Randomized Controlled Trial Multicenter StudyBreast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.
For most older women with early breast cancer, standard treatment after breast-conserving surgery is adjuvant whole-breast radiotherapy and adjuvant endocrine treatment. We aimed to assess the effect omission of whole-breast radiotherapy would have on local control in older women at low risk of local recurrence at 5 years. ⋯ Chief Scientist Office (Scottish Government), Breast Cancer Institute (Western General Hospital, Edinburgh).