The lancet oncology
-
The lancet oncology · Jul 2015
Randomized Controlled Trial Multicenter StudyMetformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial.
In preclinical work and retrospective population studies, the anti-diabetic drug metformin has been associated with antineoplastic activity and decreased burden of many cancers, including pancreatic cancer. There is therefore interest in the hypothesis that this drug might be repurposed for indications in oncology. We aimed to assess the efficacy of the addition of metformin to a standard systemic therapy in patients with advanced pancreatic cancer, and provide the first report of a clinical trial with a survival endpoint of metformin for an oncological indication. ⋯ Academic Medical Centre, Amsterdam, and The Terry Fox Foundation, Vancouver, Canada.
-
The lancet oncology · Jul 2015
ReviewContinued value of adjuvant anthracyclines as treatment for early breast cancer.
Anthracyclines are frequently used in the adjuvant treatment of early-stage breast cancer. However, with the increasing use of other active drugs--mainly taxanes and trastuzumab in HER2-positive disease--coupled with concerns about anthracycline-associated toxic effects, there is debate about whether anthracyclines are still needed. Three major factors should be taken into consideration with the investigation of the role of anthracyclines in management of early breast cancer; specifically, the proven efficacy of anthracyclines in breast cancer, the absence of superiority of non-anthracycline-based chemotherapy over anthracycline-taxane regimens, and the low risk of toxic effects associated with the cumulative doses of anthracyclines used in contemporary regimens. The risks remain substantially outweighed by the benefits of treatment with anthracyclines, and thus, they maintain an important role in adjuvant treatment of breast cancer, particularly in women with high-risk disease.
-
The lancet oncology · Jul 2015
Randomized Controlled Trial Comparative StudyPalbociclib for hormone receptor-positive breast cancer.
-
The lancet oncology · Jul 2015
Randomized Controlled TrialMismatch repair deficiency predicts benefit of anti-PD-1 therapy.