Current pain and headache reports
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Curr Pain Headache Rep · Dec 2010
ReviewTension type headache in adolescence and childhood: where are we now?
Tension type headache (TTH) is a primary headache disorder considered common in children and adolescents. It remains debatable whether TTH and migraine are separate biological entities. This review summarizes the most recent literature of TTH with regards to children and adolescents. Further studies of TTH are needed to develop a biologically based classification system that may be facilitated through understanding changes in the developing brain during childhood and adolescence.
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Curr Pain Headache Rep · Dec 2010
ReviewManaging pain in the elderly population: pearls and pitfalls.
While pain is a common symptom among older adults, it often is underdiagnosed and undertreated. Aging-related physiological changes, misperceptions about the use of pain medications by both patients and providers, and the lack of evidence-based clinical research on pain management in older adults are some of the reasons why pain in older adults is mismanaged. Using extrapolated evidence from pain research in younger patients, consensus statements, and best practice guidelines, this article summarizes and highlights areas of geriatric pain assessment and management that need special consideration. Some highlighted areas include 1) pain assessment in cognitively impaired patients; 2) medication choice and initiation doses; 3) duration of adequate medication trials; and 4) common medication side effects and suggested management.
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Curr Pain Headache Rep · Dec 2010
ReviewTension-type headache and women: do sex hormones influence tension-type headache?
Most of the world's population has suffered from a tension-type headache (TTH) at some point in their lives. The pathophysiology of this disease is not well understood, but TTH shares many features with migraine, leading to the belief that TTH and migraine may be on different ends of the same disease spectrum. There are many shared triggers between migraine and TTH, menstruation being one of them. Does menses being a trigger for TTH make TTH more like migraine, or does the role of sex hormones in TTH give us insight into the unique pathophysiology of this disease? This article will review TTH, concentrating on the role of sex hormones as a trigger for TTH.
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Curr Pain Headache Rep · Dec 2010
Patient-derived determinants for participation in placebo-controlled clinical trials for fibromyalgia.
Perspectives of patients with fibromyalgia influence their likelihood of participating in randomized placebo-controlled trials and potentially clash with current, well-established methodology of randomized controlled trial design. Mandates to use only acetaminophen for breakthrough pain and that require discontinuation of concomitant medications, especially in studies lacking an active comparator arm, could bias a trial cohort to thereby reduce the generalizability of study findings and conclusions. This study evaluates factors affecting willingness to participate in such clinical trials, including the impact of altruism, payment, study duration, forced discontinuation of specific medications, and subject demographics for patients seen by rheumatologists proficient and avidly interested in treating fibromyalgia.
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Curr Pain Headache Rep · Oct 2010
ReviewSex hormones and pain: the evidence from functional imaging.
There is a substantial body of epidemiological and clinical evidence suggesting that the sex hormones, particularly estradiol and progesterone, play a role in pain. Behavioral studies have not been useful in understanding the relationship between sex hormones and pain perception, and certainly have not helped to elucidate the mechanisms by which such effects may be mediated. ⋯ Functional imaging techniques and experimental designs are discussed before the literature investigating specific questions relating to hormones and pain is reviewed. Finally, we conclude by considering how results of studies imaging the influence of sex hormones in related areas such as emotion and cognition also may inform our understanding of this complex area.