Clinical medicine (London, England)
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Case Reports
Lesson of the month 2: Fever, arthralgias and hyperkeratotic, scaling and fissuring eruptions of the hands.
A 56-year-old male hairdresser, presented with fever and arthralgias. He had a worsening 'eczematous' palmar rash which had been attributed to irritation from colouring products used in his work. On examination, hyperkeratotic, fissuring eruptions were noted on the palmar side of his fingers and lung auscultation revealed crackles on both lower lobes. ⋯ This is a characteristic semiology reminiscent of hands of manual workers, resembling hand eczema. 'Mechanic's hands', fever, arthralgias, lung findings and elevated serum muscle enzymes raised the possibility of antisynthetase syndrome. Testing for myositis autoantibodies revealed anti-Jo-1 and anti-Ro52 reactivity supporting the diagnosis. Greater awareness of the typical clinical feature of 'mechanic's hands' will allow for earlier diagnosis and appropriate treatment in patients with antisynthetase syndrome.
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Bronchiectasis is a chronic inflammatory condition with a diverse aetiology including recurrent infections, genetic abnormalities, immunodeficiency and autoimmune disorders. The prevalence has increased over the past few years and this may be due to better imaging and diagnostic techniques. Management remains the emphasis for improving symptoms and reducing exacerbations. This article focuses on highlighting the latest data released since 2014 on new diagnostic techniques as well as potential future pharmacological and non-pharmacological treatment options for patients with bronchiectasis.
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Lung and pleural malignancies remain common in the UK with poor survival rates due, at least in part, to late stage diagnosis. Diagnostic pathways aim to reduce the time taken for patients to reach a diagnosis and treatment, with the use of positron emission tomography and endobronchial ultrasound to provide staging information alongside diagnostics. ⋯ In the UK, screening for lung cancer remains in its infancy, but provides a promising possibility for capturing curative disease. We provide an overview of the diagnostic process, therapeutic options and potential future screening programmes in pleural and pulmonary malignancies.
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Obesity is a major health and economic crisis facing the modern world. It is associated with excess mortality and morbidity and is directly linked to common conditions such as type 2 diabetes mellitus, coronary heart disease and sleep apnoea. The management of obesity and its associated complications has evolved in recent years, with a shift towards more definitive strategies such as bariatric surgery. This review encompasses the dietary, pharmacological and surgical strategies currently available for the management of obesity.