Internal medicine journal
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Internal medicine journal · May 2012
Proton pump inhibitors and diarrhoea related to Clostridium difficile infection in hospitalised patients: a case-control study.
The incidence and disease severity of Clostridium difficile infection are rising. There is increasing evidence of a potential association between proton-pump inhibitors (PPI) and C. difficile infection. ⋯ A restricted analysis on those who had exposure to antibiotics within 3 months before the onset of diarrhoea did not change the negative association between PPI exposure and PCR-proven C. difficile infection. Long-term PPI usage and intensity of PPI exposure prior to onset of diarrhoea were not significantly associated with C. difficile infection.
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Internal medicine journal · May 2012
Leukaemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms: are Asian patients different?
Leukaemic transformation (LT) is rare in the natural history of Philadelphia(Ph) chromosome-negative myeloproliferative disorders (MPD), and has a dismal prognosis. Little literature is available on Asian patients. ⋯ LT of Ph chromosome-negative MPD is rare and uniformly fatal. Despite chemotherapy, survival was poor, and patients succumbed to refractory disease and infections. Asian patients did not have a more favourable outcome. It remains to be investigated whether upfront stem cell transplant may be a treatment option.
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Internal medicine journal · May 2012
Case ReportsUtility of atrial temporary pacing as an acute treatment for bradyarrhythmias and tachyarrhythmias in the intensive care setting with preservation of atrioventricular synchrony.
Temporary pacing is often used as an acute treatment of bradyarrhythmias and suppression of tachyarrhythmias. In patients with cardiogenic shock, loss of atrioventricular synchrony may worsen cardiovascular haemodynamics. We present a series where temporary right atrial pacing was used as an acute treatment for both bradyarrhythmias and tachyarrhythmias.