Internal medicine journal
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Internal medicine journal · Sep 2018
Multicenter StudySuboptimal behaviour and knowledge regarding overnight glycaemia in adults with type 1 diabetes is common.
In people with type 1 diabetes (T1D), nocturnal hypoglycaemia (NH) can be slept through and can cause seizures, arrhythmias and death. Hypoglycaemia avoidance can induce hyperglycaemia and ketosis. Patient behaviour impacts clinical outcomes and may be changed by education. ⋯ Many adults with T1D have suboptimal knowledge and behaviour regarding overnight BG self-management. A survey, piloted herein, may facilitate the identification of patients who could benefit from further education.
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Internal medicine journal · Sep 2018
Multicenter StudyClinical risk factors for acute ischaemic and haemorrhagic stroke in patients with infective endocarditis.
Stroke as a complication of infective endocarditis portends a poor prognosis, yet risk factors for stroke subtypes have not been well defined. ⋯ Among patients with IE, there exist characteristics that relate differentially to ischaemic and haemorrhagic stroke risk.
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Internal medicine journal · May 2017
Multicenter StudyBronchial thermoplasty in severe asthma in Australia.
Bronchial thermoplasty (BT) is an approved bronchoscopic intervention for the treatment of severe asthma. However, limited published experience exists outside of clinical trials regarding patient selection and outcomes achieved. ⋯ BT is a safe procedure which can achieve clinical improvement in those with uncontrolled symptoms and severe airflow obstruction.
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Internal medicine journal · Sep 2016
Multicenter Study Observational StudyEffectiveness and response predictors of omalizumab in a severe allergic asthma population with a high prevalence of comorbidities: the Australian Xolair Registry.
Severe asthma is a high impact disease. Omalizumab targets the allergic inflammatory pathway; however, effectiveness data in a population with significant comorbidities are limited. ⋯ Australian patients with severe allergic asthma report a high disease burden and have extensive comorbidity. Symptomatic response to omalizumab was high despite significant comorbid disease. Omalizumab is an effective targeted therapy for severe allergic asthma with comorbidity in a real-life setting.
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Internal medicine journal · Sep 2016
Multicenter StudyInconsistencies and time delays in site-specific research approvals hinder collaborative clinical research in Australia.
The aim of this study was to describe the time and documentation needed to gain ethics and governance approvals in Australian states with and without a centralised ethical review system. ⋯ The benefits of centralised ethics review systems have not been realised due to duplicative, inflexible governance processes. A system that allowed the recognition of prior ethical approval and low-risk applications was more efficient than a central ethics and site-specific governance process.