The spine journal : official journal of the North American Spine Society
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Randomized Controlled Trial Clinical Trial
Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages.
In a large series of human patients undergoing open anterior lumbar interbody fusion with a tapered titanium fusion cage, recombinant human bone morphogenetic protein type 2 (rhBMP-2) on an absorbable collagen sponge carrier has been shown to decrease operative time and blood loss, to promote osteoinduction and fusion and to be a safe and effective substitute for iliac crest harvesting. ⋯ This small multicenter, randomized, nonblinded trial showed few statistically significant differences between the study groups. Both groups showed comparable improvements on outcome scores. Overall results show that the use of rhBMP-2 can eliminate the need for harvesting iliac crest graft and may be an equivalent replacement for autograft for use in successful posterior lumbar interbody fusions. Further studies of the use of rhBMP-2 in posterior lumbar interbody fusion cage procedures are needed.
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Randomized Controlled Trial Clinical Trial
Preemptive analgesia for postoperative pain relief in lumbosacral spine surgeries: a randomized controlled trial.
Administration of analgesic medication, before the actual onset of painful stimulus, is more effective than that after the onset of painful stimulus. This is the principle of preemptive analgesia. Although it is often considered superior to other forms of analgesia, its role in postoperative pain relief after lumbosacral spinal surgery has not been fully investigated. ⋯ Preemptive analgesia with a single caudal epidural injection of bupivacaine and tramadol is a safe, simple and effective method for postoperative pain relief.
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Randomized Controlled Trial Clinical Trial
A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain.
Intradiscal electrothermal therapy (IDET) is a treatment for discogenic low back pain the efficacy of which has not been rigorously tested. ⋯ Nonspecific factors associated with the procedure account for a proportion of the apparent efficacy of IDET, but its efficacy cannot be attributed wholly to a placebo effect. The results of this trial cannot be generalized to patients who do not fit the strict inclusion criteria of this study, but IDET appears to provide worthwhile relief in a small proportion of strictly defined patients undergoing this treatment for intractable low back pain.
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Randomized Controlled Trial Clinical Trial
Effects of aerobic exercise on low back pain patients in treatment.
Aerobic exercise (AE) has been prescribed to improve fitness and well-being in apparently healthy individuals and cardiac, orthopedic, and other patient populations. AE has not previously been studied as a sole treatment for low back pain patients (LBPP). ⋯ Low to moderate aerobic exercise appears to improve mood states and work status and reduce the need for physical therapy referrals and pain medication prescriptions for LBPP in the care of a neurosurgeon.