Articles: learning-physiology.
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Semin Pediatr Neurol · Dec 2005
ReviewDisorders of attention or learning in neurodevelopmental disorders.
Disorders of attention or learning commonly accompany neurodevelopmental disorders. The evaluation and diagnosis of these disorders is complex and does not always follow techniques used for typically developing children. These disorders are often underappreciated and inadequately addressed because they are overshadowed by the neurodevelopmental disorder. Nevertheless, failure to recognize, diagnose, and manage these disorders may result in unsuccessful community integration.
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If neurobiology is ultimately to contribute to the development of successful treatments for drug addiction, researchers must discover the molecular mechanisms by which drug-seeking behaviors are consolidated into compulsive use, the mechanisms that underlie the long persistence of relapse risk, and the mechanisms by which drug-associated cues come to control behavior. Evidence at the molecular, cellular, systems, behavioral, and computational levels of analysis is converging to suggest the view that addiction represents a pathological usurpation of the neural mechanisms of learning and memory that under normal circumstances serve to shape survival behaviors related to the pursuit of rewards and the cues that predict them. The author summarizes the converging evidence in this area and highlights key questions that remain.
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Neurosci Biobehav Rev · Jan 2005
Review Biography Historical ArticleDonald O. Hebb's synapse and learning rule: a history and commentary.
This year sees the anniversary of Donald O. Hebb's birth, in July 1904. ⋯ His core postulate, which gave rise to such eponymous expressions as the Hebbian synapse and the Hebbian learning rule, is examined in some detail, as well as the part it played in his higher-order theoretical constructs concerned with neocortical structure and function. Early models which made use of the Hebbian synapse are described, and then illustrative examples are given detailing the impact of Hebb's idea in relation to learning and memory, synaptic plasticity and stability, and the question of persistent cortical activity underlying forms of short-term memory.
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Neurobiol Learn Mem · Jul 1998
Review Comparative StudyA comparative perspective on motor learning.