Articles: analgesics.
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J Bone Joint Surg Am · Dec 1995
Randomized Controlled Trial Comparative Study Clinical TrialEpidural administration of methylprednisolone and morphine for pain after a spinal operation. A randomized, prospective, comparative study.
The results of postoperative epidural administration of saline solution (a placebo), morphine, methylprednisolone, and a combination of morphine and methylprednisolone for the reduction of pain after an operation for spinal stenosis or a herniated intervertebral disc were compared in a prospective, randomized blinded study. Epidural administration of morphine and methylprednisolone--either alone or in combination--significantly reduced the need for analgesia after an operation for spinal stenosis (p < 0.05) but not after an operation for a herniated intervertebral disc. ⋯ Itching was significantly more common in the patients who had received morphine than in those who had received the placebo (p = 0.04). Although urinary retention was more frequent after the use of morphine than after the use of the placebo, the difference was not significant with the size of the sample that was analyzed (p = 0.25).
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Randomized Controlled Trial Comparative Study Clinical Trial
[Acceptability of high colonoscopy using different premedication--a comparison of the effect of midazolam versus midazolam and pethidine from the viewpoint of the patient and the physician].
Invasive endoscopic procedures such as total colonoscopy result in a better patient acceptance, the less discomfort they cause. Therefore a premedication for total colonoscopy is often required. In a prospective, double-blind, placebo-controlled clinical study of 132 patients examined by one experienced endoscopist we compared two premedication schedules: midazolam (mean 5.2 mg i.v.) versus midazolam (mean 4.8 mg) plus pethidin (50 mg). ⋯ It was also shown, that the endoscopist scored a higher degree of patient's pain during the examination than the patient did himself. No more negative side-effects such as decrease of arterial partial pressure of oxygen or cardiopulmonary complications were found using the combination of both drugs; they provided to be safe without added risk of hypoxia. Thus, the combination of both drugs can be given as premedication for total colonoscopy.
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Minerva anestesiologica · Dec 1995
Randomized Controlled Trial Clinical Trial[Evaluation of the synergism between ketorolac and morphine in the treatment of postoperative pain].
The aim of the study is to determine what concentration of ketorolac and morphine administered together i.v. achieve best synergic effect between NSAID antiinflammatory and opioids analgesic properties. ⋯ Results suggest a greater synergetic effect between morphine and ketorolac in concentrations used in group 2.
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J Paediatr Child Health · Dec 1995
Randomized Controlled Trial Clinical TrialAnalgesia for venepuncture in a paediatric surgery centre.
To establish an effective and efficient method of painless venepuncture in children 8 years and older in an ambulatory paediatric surgery centre. ⋯ Oral midazolam in combination with 50% nitrous oxide provides adequate analgesia and anxiolysis for venepuncture in patients 8 years and older. The addition of EMLA cream or intradermal lidocaine will decrease the likelihood of patient movement.
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Fortschritte der Medizin · Nov 1995
Randomized Controlled Trial Multicenter Study Clinical Trial[Effectiveness of flupirtine in chronic tension headache. Results of a double-blind study versus placebo].