Articles: analgesics.
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study.
We aimed to identify doses of mirogabalin (DS-5565) providing clinically meaningful efficacy with manageable side effects for treatment of diabetic peripheral neuropathic pain (DPNP). ⋯ Mirogabalin 15, 20, and 30 mg/day had statistically significant reductions in ADPS versus placebo, and mirogabalin 30 mg/day also met the criteria of minimally meaningful effect. Mirogabalin may be a promising new treatment option for patients with DPNP.
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Drug Alcohol Depend · Dec 2014
Randomized Controlled Trial Multicenter StudyAssessing craving and its relationship to subsequent prescription opioid use among treatment-seeking prescription opioid dependent patients.
Craving is viewed as a core feature of substance use disorders and has been shown to predict future drug use, particularly over the short term. Accordingly, craving is often assessed in treatment settings as a marker of risk for subsequent drug use. The identification of the briefest measure that maintains predictive validity is of particular value for both clinical and research settings to minimize assessment burden while maintaining utility for the prediction of use. ⋯ A brief measure of prescription opioid craving predicted prescription opioid use among individuals in treatment. This measure offers an efficient strategy to inform the assessment of risk for use in this population.
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Multicenter Study
Clinical and genetic factors related to cancer-induced bone pain and bone pain relief.
The study objective was to evaluate whether there are clinical or genetic differences between patients with cancer-induced bone pain (CIBP) and patients with non-CIBP, and, in the CIBP group, in those with good versus poor opioid response. ⋯ Patients with CIBP who were taking opioids had a clinical profile slightly different from that of the non-CIBP group. However, no specific genetic pattern emerged for CIBP versus non-CIBP or for responsive versus nonresponsive patients with CIBP.
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Randomized Controlled Trial Multicenter Study
Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial.
Regular paracetamol is the recommended first-line analgesic for acute low-back pain; however, no high-quality evidence supports this recommendation. We aimed to assess the efficacy of paracetamol taken regularly or as-needed to improve time to recovery from pain, compared with placebo, in patients with low-back pain. ⋯ National Health and Medical Research Council of Australia and GlaxoSmithKline Australia.
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Multicenter Study
Effectiveness of opioid rotation in the control of cancer pain: the ROTODOL study.
To assess the effectiveness of opioid rotation (OR) to manage cancer pain. To describe the adverse events (AEs) associated with OR. ⋯ Opioid rotation appears to be both safe and effective in the management of basal and breakthrough cancer pain.